Ding Wen, Zhang Fu-Li, Liu Xiao-Cong, Hu Lin-Li, Dai Shan-Jun, Li Gang, Kong Hui-Juan, Guo Yi-Hong
Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Henan Key Laboratory of Reproduction and Genetics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Endocrinol (Lausanne). 2019 Aug 2;10:516. doi: 10.3389/fendo.2019.00516. eCollection 2019.
Female overweight/obesity has been reported to be associated with compromised pregnancy outcomes in fresh embryo transfer cycles. It is unclear whether the cumulative live birth rate (CLBR) is adversely affected after all viable embryos are transferred from the first ovarian stimulation cycle. To investigate whether the CLBR was compromised in obese women. A total of 9,772 young women underwent their first IVF/ICSI cycles from January 2012 to October 2017. Pregnancy outcomes were compared according to female BMI. Among 1,671 women with polycystic ovary syndrome (PCOS), those with a BMI ≥ 28 kg/m had a lower cumulative clinical pregnancy rate (CCPR) and CLBR during the first complete ovarian stimulation cycle. Additionally, the pregnancy loss rate was increased in this group, although the difference was not significant. Among the 8,101 women without PCOS, the CCPR and CLBR of obese patients was also significantly decreased, and this group also showed increased pregnancy loss rates. Moreover, overweight women also had a decreased CLBR. Female obesity adversely affected the CLBR after utilizing the viable embryos from first oocytes retrieval.
据报道，在新鲜胚胎移植周期中，女性超重/肥胖与妊娠结局受损有关。目前尚不清楚在首次卵巢刺激周期中所有可存活胚胎移植后，累积活产率（CLBR）是否会受到不利影响。为了研究肥胖女性的CLBR是否受损，2012年1月至2017年10月期间，共有9772名年轻女性接受了她们的首次体外受精/卵胞浆内单精子注射（IVF/ICSI）周期。根据女性体重指数（BMI）比较妊娠结局。在1671名多囊卵巢综合征（PCOS）女性中，BMI≥28kg/m²的女性在第一个完整卵巢刺激周期中的累积临床妊娠率（CCPR）和CLBR较低。此外，该组的妊娠丢失率有所增加，尽管差异不显著。在8101名无PCOS的女性中，肥胖患者的CCPR和CLBR也显著降低，且该组妊娠丢失率也有所增加。此外，超重女性的CLBR也有所下降。在利用首次取卵获得的可存活胚胎后，女性肥胖对CLBR产生了不利影响。
