健康成年人中SSAT-1活性增加的预测价值及临床意义
Predictive value and clinical significance of increased SSAT-1 activity in healthy adults.
作者信息
Tappia Paramjit S, Maksymiuk Andrew W, Sitar Daniel S, Akhtar Parveen S, Khatun Nazrina, Parveen Rahnuma, Ahmed Rashiduzzaman, Ahmed Rashid B, Cheng Brian, Huang Gina, Bach Horacio, Hiebert Brett, Ramjiawan Bram
机构信息
Asper Clinical Research Institute & Office of Clinical Research, St Boniface Hospital, Winnipeg, MB, R2H 2A6, Canada.
Cancer Care Manitoba, Winnipeg, MB, R3E 0V9, Canada.
出版信息
Future Sci OA. 2019 Jul 1;5(7):FSO400. doi: 10.2144/fsoa-2019-0023.
AIM
Spermidine/spermine N-acetyltransferase (SSAT-1) regulates cell growth, proliferation and death. Amantadine is converted by SSAT-1 to acetylamantadine (AA). In our earlier studies, although SSAT-1 was activated in patients with cancer, a number of ostensibly healthy adult volunteers had higher than expected AA concentration. This study was therefore undertaken to examine the outlier group.
MATERIALS & METHODS: A follow up of urine analysis for AA by liquid chromatography-tandem mass spectrometry as well as clinical assessments and additional blood analyses were conducted.
RESULTS
In some of the outlier controls, higher than expected AA concentration was linked to increased serum carcinoembryonic antigen. Clinical and radiographic assessments revealed underlying abnormalities in other cases that could represent premalignant conditions. Hematology tests revealed elevations in white blood cells and platelets, which are markers of inflammation.
CONCLUSION
High urine concentration of AA could be used as a simple and useful test for screening of cancer in high-risk populations.
目的
亚精胺/精胺N-乙酰基转移酶（SSAT-1）调节细胞生长、增殖和死亡。金刚烷胺被SSAT-1转化为乙酰金刚烷胺（AA）。在我们早期的研究中，尽管癌症患者体内的SSAT-1被激活，但一些表面上健康的成年志愿者的AA浓度高于预期。因此，本研究旨在对异常值组进行检查。
材料与方法
采用液相色谱-串联质谱法对尿液中的AA进行分析随访，并进行临床评估和额外的血液分析。
结果
在一些异常值对照组中，高于预期的AA浓度与血清癌胚抗原升高有关。临床和影像学评估在其他病例中发现了可能代表癌前病变的潜在异常。血液学检查显示白细胞和血小板升高，这是炎症的标志物。
结论
尿液中AA的高浓度可作为高危人群癌症筛查的一种简单且有用的检测方法。
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