亚精胺/精胺-N-乙酰转移酶-1作为人类癌症的诊断生物标志物
Spermidine/spermine -acetyltransferase-1 as a diagnostic biomarker in human cancer.
作者信息
Maksymiuk Andrew W, Sitar Daniel S, Ahmed Rashid, Cheng Brian, Bach Horacio, Bagchi Rushita Adhikari, Aroutiounova Nina, Tappia Paramjit S, Ramjiawan Bram
机构信息
Cancer Care Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada.
Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3A 1R9, Canada.
出版信息
Future Sci OA. 2018 Sep 10;4(10):FSO345. doi: 10.4155/fsoa-2018-0077. eCollection 2018 Dec.
AIM
SSAT-1 is an enzyme that plays a critical role in cell growth. Amantadine, a FDA-approved antiviral drug, is a substrate for SSAT-1. The utility of amantadine as an agent to demonstrate elevated SSAT-1 activity linked to cancer was conducted.
RESULTS
High levels of SSAT-1 expression were measured in tumor human cell lines, and in breast, prostate and lung tumor tissue. An increase in the urinary levels of acetylated amantadine in cancer patients was observed.
CONCLUSION
Increases in SSAT-1 contents in tumor tissue could be of value in targeting cancers with high SSAT-1 expression for confirmation/quantification. The high levels of acetylated amantadine could be used as a simple and useful screening test for the presence of cancer.
目的
SSAT-1是一种在细胞生长中起关键作用的酶。金刚烷胺是一种经美国食品药品监督管理局批准的抗病毒药物，是SSAT-1的底物。本研究探讨了金刚烷胺作为一种用于证明与癌症相关的SSAT-1活性升高的药物的效用。
结果
在人类肿瘤细胞系以及乳腺、前列腺和肺部肿瘤组织中检测到高水平的SSAT-1表达。观察到癌症患者尿液中乙酰化金刚烷胺水平升高。
结论
肿瘤组织中SSAT-1含量的增加对于靶向高SSAT-1表达的癌症进行确认/定量可能具有价值。高水平的乙酰化金刚烷胺可作为一种简单且有用的癌症筛查检测方法。
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