Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02435, Republic of Korea.
Biomed Res Int. 2019 Jul 24;2019:1926352. doi: 10.1155/2019/1926352. eCollection 2019.
The mortality of individuals suffering from depression has been increasing, noticeably of postmenopausal women; consequently, their care and treatment are significant to retain a high quality of life. The aim of this study was to examine the effect of (CS) on repeated stress-induced changes of the depression related function on the tail suspension test (TST), forced swimming test (FST) in ovariectomized female rats. After behavioral test, we evaluated the changes in the neurotransmitter by measuring the level of dopamine in the nucleus accumbens (NaC) and the serum levels of estrogen and oxytocin. We used 18F-2-fluoro-deoxy-D-glucose positron emission tomography (18F-FDG-PET) to examine the effects of CS on glucose metabolism in ovariectomized rats. Female rats were randomly segregated into three groups. Nor group was considered as nonoperated and nonstressed group, while the control was the ovariectomized and stressed group (OVX+ST), and CS was the ovariectomized, stressed and CS treated group. The rats were exposed to immobilization stress (IMO) for 14 d (2 h/d), and CS (300 mg/kg, i.p.) was treated 30 min before IMO stress. Significant reduction of immobility in the TST and FST was indicated in rats treatment with CS compared to the control group (OVX+ST). The levels of estrogen in the serum of the Nor and CS groups were significantly elevated compared to the OVX+ST group. Also, CS activated brain glucose metabolism in the cortex. The present findings suggested that CS had antidepressant effectiveness in a menopausal depression animal model. These findings suggest evidence that CS plays a crucial role in stressful situation, providing that CS might be a dependable antidepressant medicine to treat menopausal depression.
患有抑郁症的个体的死亡率一直在上升，尤其是绝经后妇女；因此，保持她们的护理和治疗水平对于维持高质量的生活至关重要。本研究旨在研究（CS）对反复应激诱导的抑郁相关功能变化在悬尾试验（TST）、强迫游泳试验（FST）中的影响，对去卵巢雌性大鼠。行为测试后，我们通过测量伏隔核（NaC）中的多巴胺水平和血清雌激素和催产素水平来评估神经递质的变化。我们使用 18F-2-氟-脱氧-D-葡萄糖正电子发射断层扫描（18F-FDG-PET）检查 CS 对去卵巢大鼠葡萄糖代谢的影响。雌性大鼠被随机分为三组。Nor 组被认为是未手术和未应激组，而对照是去卵巢和应激组（OVX+ST），CS 是去卵巢、应激和 CS 治疗组。大鼠接受固定应激（IMO）14 d（2 h/d），CS（300 mg/kg，ip）在 IMO 应激前 30 分钟处理。与对照组（OVX+ST）相比，CS 治疗的大鼠 TST 和 FST 的不动时间明显减少。与 OVX+ST 组相比，Nor 和 CS 组血清中的雌激素水平显著升高。此外，CS 激活了大脑皮质的葡萄糖代谢。本研究结果表明，CS 对绝经后抑郁症动物模型具有抗抑郁作用。这些发现表明 CS 在应激情况下发挥着重要作用，提供了 CS 可能是一种可靠的抗抑郁药物来治疗绝经后抑郁症的证据。
