Department of Rheumatology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, China.
Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
J Immunol Res. 2019 Jul 24;2019:4080735. doi: 10.1155/2019/4080735. eCollection 2019.
Rheumatoid arthritis (RA) and osteoarthritis (OA) are common rheumatic disorders that primarily involve joints. The inflammation of the synovium can be observed in both of the two diseases. Synovial fibroblasts (SFs) play an important role in the inflammatory process of the synovium. The functional states of synovial fibroblasts are heterogeneous, and the detailed transition process of their functional states is still unclear. By using transcriptomic data of SFs at a single-cell level, we found a similar transition process for SFs in RA and OA. We also identified the potential regulatory effects of the WNT signaling pathway, the TGF- signaling pathway, the FcRI signaling pathway, and the ERBB signaling pathway on modifying the SFs' functional state. These findings indicate potentially overlapped pathogenic mechanisms in these two diseases, which may help uncover new therapeutic targets to ameliorate disease progression.
类风湿关节炎（RA）和骨关节炎（OA）是两种常见的风湿性疾病，主要涉及关节。这两种疾病均可观察到滑膜炎症。滑膜成纤维细胞（SFs）在滑膜炎症过程中起着重要作用。滑膜成纤维细胞的功能状态具有异质性，其功能状态的详细转变过程尚不清楚。通过使用单细胞水平的 SFs 转录组数据，我们发现 RA 和 OA 中的 SFs 具有相似的转变过程。我们还鉴定了 WNT 信号通路、TGF-信号通路、FcRI 信号通路和 ERBB 信号通路对修饰 SFs 功能状态的潜在调节作用。这些发现表明这两种疾病可能存在潜在的重叠发病机制，这可能有助于发现新的治疗靶点来改善疾病进展。
