Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Jinan, Shandong 250022, People's Republic of China.
Chem Commun (Camb). 2019 Sep 16;55(72):10776-10779. doi: 10.1039/c9cc03114f. Epub 2019 Aug 21.
Herein, we present a dual-site ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the detection of pH in the ER. The probe showed a highly sensitive response to pH in the range of 5.0-7.2, and could be applied for the quantitative measurement of the pH values in the ER during ER stress and dexamethanose-induced stimulation.
在此，我们提出了一种基于 ICT-PET-FRET 机制的双位点比率荧光探针，用于检测内质网中的 pH 值。该探针对 pH 值在 5.0-7.2 范围内具有高度敏感的响应，可用于定量测量内质网应激和地塞米松诱导刺激期间内质网中 pH 值。
