通过不对称醇介导的羰基还原偶联实现 Phosdiecin A 的全合成及结构确证。
Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling.
机构信息
Institute of Chemistry , University of Campinas (UNICAMP) , P.O. Box 6154, CEP 13083-970 Campinas , São Paulo , Brazil.
Department of Chemistry , University of Texas at Austin , Austin , Texas 78712 , United States.
出版信息
J Am Chem Soc. 2019 Sep 4;141(35):13778-13782. doi: 10.1021/jacs.9b07512. Epub 2019 Aug 21.
Abstract
The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. The present route is the shortest among >30 total and formal syntheses of fostriecin family members.
摘要
通过不对称铱催化的醇介导的羰基还原偶联反应，完成了 13 步反应的 phosdiecin A 的首次全合成和结构确证。该路线是 fostriecin 家族成员的 30 多个全合成和形式合成中最短的路线。
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