Department of Nutrition, Federal University of Piauí, Campus Minister Petrônio Portela, Ininga, Teresina, Piauí, Brazil.
Laboratory Med Imagem, Center (South), Teresina, Piauí, Brazil.
Int J Vitam Nutr Res. 2021 Jan;91(1-2):40-47. doi: 10.1024/0300-9831/a000600. Epub 2019 Aug 21.
Obesity is characterized by changes in the metabolism of zinc and thyroid hormones. Studies have also shown the role of zinc in the function and metabolism of thyroid. The present study aimed to evaluate the relationship between serum concentrations of thyroid hormones, dietary zinc intake and zinc distribution in obese women. A case-control study was conducted enrolling 98 women aged between 20 and 50 years old who were divided into case group (BMI ≥ 35 kg/m) and control group (BMI = 18.5-24.9 kg/m). Patients underwent anthropometric measurements and analysis of dietary zinc intake, which was performed by a three-day food record. Zinc concentrations in plasma and erythrocytes were determined by inductively coupled plasma optical emission spectrometry. Serum concentrations of thyroid hormones and antibodies were determined by chemiluminescence. Mean values of dietary zinc intake were higher than recommended (10.37 ± 3.12 mg/day and 11.37 ± 4.36 mg/day for control and obeses, respectively). Obese women had reduced plasma (67.22 ± 5.96 μg/dL) and erythrocyte (37.16 ± 3.64 μg Zn/gHb) zinc concentrations when compared to the control group (plasma: 89.71 ± 13.33 μg/dL; erythrocyte: 42.68 ± 3.73 μg Zn/gHb) (p < 0.001). Serum TSH (control: 2.62 ± 1.29 μIU/mL; obeses: 3.08 ± 1.13 μIU/mL), Free T3 (control: 2.19 ± 0.63 pg/dL; obeses: 2.09 ± 0.34 pg/dL), and Free T4 (control: 1.12 ± 0.31 ng/dL; obeses: 1.09 ± 0.19 ng/dL) concentrations were within the normal range in both groups, without significant difference between them (p > 0.05). There was no correlation between thyroid hormone concentrations and zinc parameters (p > 0.05). Although obese women presented hypozincemia, they had normal levels of thyroid hormones and no correlation was found between the studied parameters.
肥胖症的特点是锌和甲状腺激素代谢的变化。研究还表明了锌在甲状腺功能和代谢中的作用。本研究旨在评估甲状腺激素血清浓度、膳食锌摄入量和肥胖女性体内锌分布之间的关系。进行了一项病例对照研究，共纳入 98 名年龄在 20 至 50 岁之间的女性，分为病例组（BMI≥35kg/m）和对照组（BMI=18.5-24.9kg/m）。患者接受了人体测量学测量和膳食锌摄入量分析，通过为期三天的食物记录来进行。通过电感耦合等离子体发射光谱法测定血浆和红细胞中的锌浓度。通过化学发光法测定甲状腺激素和抗体的血清浓度。膳食锌摄入量的平均值高于推荐值（对照组为 10.37±3.12mg/天，肥胖组为 11.37±4.36mg/天）。与对照组相比，肥胖女性的血浆（67.22±5.96μg/dL）和红细胞（37.16±3.64μg Zn/gHb）锌浓度降低（血浆：89.71±13.33μg/dL；红细胞：42.68±3.73μg Zn/gHb）（p<0.001）。两组血清 TSH（对照组：2.62±1.29μIU/mL；肥胖组：3.08±1.13μIU/mL）、游离 T3（对照组：2.19±0.63pg/dL；肥胖组：2.09±0.34pg/dL）和游离 T4（对照组：1.12±0.31ng/dL；肥胖组：1.09±0.19ng/dL）浓度均在正常范围内，两组间无差异（p>0.05）。甲状腺激素浓度与锌参数之间无相关性（p>0.05）。尽管肥胖女性存在低锌血症，但甲状腺激素水平正常，且研究参数之间无相关性。
