Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil.
School of Nursing, Department of Nutrition, Federal University of Minas Gerais, 6627 Av. Pres. Antônio Carlos, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Clin Nutr ESPEN. 2021 Feb;41:398-404. doi: 10.1016/j.clnesp.2020.10.012. Epub 2020 Nov 11.
Studies have been conducted with the purpose of elucidating thyroid gland dysfunction in obesity, however the contributing factors for such dysfunction are not yet fully understood. Selenium is notable for its role in thyrocyte protection against oxidative damage and control of thyroid hormone synthesis. In addition, subjects with obesity may exhibit alterations in the selenium homeostasis. Therefore, the present study aimed to examine the selenium status and its relationship with serum thyroid hormone levels in obese women.
This cross-sectional study included 69 euthyroid women, aged between 18 and 50 years, who were divided in two groups: an obese group (n = 35) and a control group with women of normal weight (n = 34). Selenium intake was assessed by three-day diet records and analyzed using NutWin software version 1.5. Plasma, erythrocyte, and urinary selenium levels were determined using inductively coupled plasma optical emission spectrometry. Testing for thyroid hormones and thyroid autoantibodies was performed based on chemiluminescence.
The median dietary selenium content was adequate according to the recommendations, with no statistical difference between groups. Obese women had reduced plasma and erythrocyte selenium levels compared to the control group, although selenium concentration in erythrocytes was adequate within the normal range for both groups. There was no significant difference between the urinary selenium concentrations in the subjects; however, the mineral clearance was higher in the obese group. Free triiodothyronine (fT3) and free thyroxine (fT4) levels were higher in obese women with class II obesity when compared to the control group. There was a negative correlation between plasma selenium and serum fT4 levels.
Obese women showed impairment in selenium homeostasis, however, this fact did not seem to adversely affect thyroid metabolism.
已有研究旨在阐明肥胖患者甲状腺功能障碍，但导致这种功能障碍的因素尚不完全清楚。硒在甲状腺细胞免受氧化损伤和控制甲状腺激素合成方面起着重要作用。此外，肥胖患者可能会出现硒稳态的改变。因此，本研究旨在检测肥胖女性的硒状态及其与血清甲状腺激素水平的关系。
本横断面研究纳入了 69 名年龄在 18 岁至 50 岁之间的甲状腺功能正常的女性，分为两组：肥胖组（n=35）和体重正常的对照组（n=34）。通过 3 天饮食记录评估硒的摄入量，并使用 NutWin 软件版本 1.5 进行分析。使用电感耦合等离子体发射光谱法测定血浆、红细胞和尿硒水平。根据化学发光法检测甲状腺激素和甲状腺自身抗体。
根据建议，中位数膳食硒含量充足，两组间无统计学差异。与对照组相比，肥胖女性的血浆和红细胞硒水平降低，但两组红细胞硒浓度均在正常范围内。受试者的尿硒浓度无显著差异；然而，肥胖组的矿物质清除率较高。与对照组相比，Ⅱ级肥胖的肥胖女性游离三碘甲状腺原氨酸（fT3）和游离甲状腺素（fT4）水平较高。血浆硒与血清 fT4 水平呈负相关。
肥胖女性的硒稳态受损，但这一事实似乎并未对甲状腺代谢产生不利影响。
