绿茶对醋酸甲羟孕酮所致血管外膜和内皮变化的保护作用。
Protective effect of green tea on tunica adventitia and endothelial changes resulting from depot medroxy progesterone acetate.
作者信息
Veri Nora, As Emilda, Mutiah Cut, Seriana Irma, Malinda Risnati
机构信息
Midwifery Study Program, Ministry of Health Polytechnic of Langsa, Aceh, Special Region of Aceh, Indonesia.
Department of Midwifery, Polytechnic of Health-Ministry of Health, Aceh, Indonesia.
出版信息
J Taibah Univ Med Sci. 2018 Nov 17;14(1):8-13. doi: 10.1016/j.jtumed.2018.10.002. eCollection 2019 Feb.
OBJECTIVE
This study aimed to analyse the effects of green tea in inhibiting uterine atrophy and vascular changes due to the use of depot medroxy progesterone acetate (DMPA).
METHODS
Twenty-five female Wistar rats aged one to two months were randomly assigned to five treatment groups: control group, DMPA-induced group, and DMPA-induced group orally treated with green tea extract (at 10.8 mg/day, 21.6 mg/day, or 43.2 mg/day). Histologic analysis of uterine and vascular tissues was performed with haematoxylin-eosin staining.
RESULTS
DMPA decreased the thickness of endometrium and tunica adventitia, as well as significantly decreased endothelial cell count ( < 0.05). DMPA-induced decreases in the thickness of tunica adventitia and endothelial cell count could be significantly inhibited by green tea extract ( < 0.05).
CONCLUSION
This study concluded that DMPA triggered the depletion of uterine endometrium and vascular tunica adventitia and decreased endothelial cell count. Green tea extract at the highest dose normalized tunica adventitia and endothelial changes to the basal value.
目的
本研究旨在分析绿茶对因使用醋酸甲羟孕酮长效注射剂（DMPA）所致子宫萎缩和血管变化的抑制作用。
方法
将25只1至2月龄的雌性Wistar大鼠随机分为五个治疗组：对照组、DMPA诱导组，以及用绿茶提取物口服治疗的DMPA诱导组（剂量分别为10.8毫克/天、21.6毫克/天或43.2毫克/天）。采用苏木精-伊红染色对子宫和血管组织进行组织学分析。
结果
DMPA降低了子宫内膜和外膜的厚度，同时显著降低了内皮细胞数量（P<0.05）。绿茶提取物可显著抑制DMPA诱导的外膜厚度降低和内皮细胞数量减少（P<0.05）。
结论
本研究得出结论，DMPA引发了子宫内膜和血管外膜的损耗，并降低了内皮细胞数量。最高剂量的绿茶提取物可使外膜和内皮变化恢复至基础值。
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