类风湿关节炎疲劳的预测因素。
Predictors of fatigue in rheumatoid arthritis.
机构信息
Centre for Epidemiology Versus Arthritis, Faculty of Biology Medicine and Health, The University of Manchester, Manchester.
Institution of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
出版信息
Rheumatology (Oxford). 2019 Nov 1;58(Suppl 5):v29-v34. doi: 10.1093/rheumatology/kez346.
Abstract
People with RA commonly experience fatigue. Fatigue is a key contributor to increased clinical care costs, primary care consultations and employment loss. Despite this, our understanding of the prognostic of factors of poor fatigue outcomes is lacking and fatigue is poorly managed. Examining longitudinal predictors of fatigue can identify both individuals 'at risk' of poor prognosis, and candidate mechanisms that are worthy of greater inspection. This review discusses the factors most commonly investigated as being implicated in the prognosis of RA fatigue. The available data appears to implicate generic factors such as pain, mental health, disability and sleep as consistent predictors of fatigue outcome, while the role of disease activity and inflammation seems less clear. However, the existing data are not without methodological limitations and there have been no specific studies primarily designed to investigate the inflammatory biomarkers of fatigue. Future studies are required to more comprehensively and robustly determine the mechanisms of fatigue.
摘要
类风湿关节炎患者通常会经历疲劳。疲劳是导致临床护理成本增加、初级保健咨询和就业损失的主要原因。尽管如此，我们对导致疲劳不良结局的预后因素的了解仍很缺乏，而且疲劳的治疗效果也很差。对疲劳的纵向预测因素进行检查，可以确定哪些人“有风险”出现预后不良，哪些候选机制值得进一步检查。本综述讨论了最常被认为与类风湿关节炎疲劳预后有关的因素。现有数据似乎表明，疼痛、心理健康、残疾和睡眠等一般因素是疲劳结局的一致预测因素，而疾病活动和炎症的作用则不太明确。然而，现有数据并非没有方法学上的局限性，也没有专门设计来研究疲劳的炎症生物标志物的研究。需要开展进一步的研究，以更全面和更有力地确定疲劳的机制。
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