Haverkorn M J
Laboratory for Medical Microbiology, Eindhoven, The Netherlands.
Eur J Clin Microbiol Infect Dis. 1988 Oct;7(5):661-4. doi: 10.1007/BF01964247.
Forty-two patients with respiratory tract infection caused by Pseudomonas aeruginosa were treated with 500 mg ciprofloxacin administered orally twice daily. Pseudomonas aeruginosa was eradicated in 22 patients but recurred in eight patients. Clinical improvement or resolution was noted in 37 patients (88%). Eradication and cure rates were highest in patients without permanent risk factors, and in patients with hospital-acquired infection. New colonization during treatment was noted in 14 patients (33%), but no superinfection occurred. In persisting strains of Pseudomonas aeruginosa the in vitro sensitivity to ciprofloxacin decreased significantly during therapy.
42例铜绿假单胞菌引起的呼吸道感染患者接受了环丙沙星治疗，口服剂量为500mg，每日两次。22例患者的铜绿假单胞菌被根除，但8例患者复发。37例患者（88%）出现临床改善或症状消退。在无永久性危险因素的患者以及医院获得性感染患者中，根除率和治愈率最高。治疗期间14例患者（33%）出现新的定植，但未发生二重感染。在持续存在的铜绿假单胞菌菌株中，治疗期间对环丙沙星的体外敏感性显著下降。
