环丙沙星、诺氟沙星、恶喹酸、西诺沙星和萘啶酸的抗菌活性。
Antibacterial activities of ciprofloxacin, norfloxacin, oxolinic acid, cinoxacin, and nalidixic acid.
作者信息
Barry A L, Jones R N, Thornsberry C, Ayers L W, Gerlach E H, Sommers H M
出版信息
Antimicrob Agents Chemother. 1984 May;25(5):633-7. doi: 10.1128/AAC.25.5.633.
In vitro studies were performed comparing ciprofloxacin (Bay o 9867) and norfloxacin with three related organic acids. Ciprofloxacin was two to eight times more active than norfloxacin against 658 bacterial isolates representing 30 species. For all species tested, ciprofloxacin MICs for 90% inhibition were less than or equal to 2.0 micrograms ml. Additional tests with 5,994 isolates detected only 37 (0.6%) strains resistant to 2.0 micrograms of ciprofloxacin per ml and 106 (1.8%) resistant to 1.0 micrograms/ml. Only 6 (0.1%) of the 5,994 strains were resistant to 16 micrograms of norfloxacin per ml, and 129 (2.1%) were resistant to 4.0 micrograms/ml. The majority of resistant strains were streptococci or Pseudomonas spp. Resistance among the Enterobacteriaceae was extremely rare (i.e., greater than 99.8% susceptible to both drugs.
进行了体外研究，比较环丙沙星（拜耳O 9867）和诺氟沙星与三种相关有机酸的抗菌活性。环丙沙星对代表30个菌种的658株细菌的活性比诺氟沙星高2至8倍。对于所有测试菌种，环丙沙星抑制90%细菌生长的最低抑菌浓度（MIC）小于或等于2.0微克/毫升。对5994株细菌进行的额外测试仅检测到37株（0.6%）对每毫升2.0微克环丙沙星耐药，106株（1.8%）对每毫升1.0微克环丙沙星耐药。在5994株细菌中，只有6株（0.1%）对每毫升16微克诺氟沙星耐药，129株（2.1%）对每毫升4.0微克诺氟沙星耐药。大多数耐药菌株为链球菌或假单胞菌属。肠杆菌科中的耐药情况极为罕见（即对两种药物的敏感性均大于99.8%）。
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