López-Brea M, Alarcón T
Servicio de Microbiología, Hospital de la Princesa, Universidad Autónoma, Madrid, Spain.
Eur J Clin Microbiol Infect Dis. 1990 May;9(5):345-7. doi: 10.1007/BF01973741.
Escherichia coli and Klebsiella pneumoniae resistant to fluoroquinolones were isolated from an infected Hickman catheter in a 43-year-old diabetic patient who had previously been treated with a 24-day course of ciprofloxacin (200 mg/12 h i.v.). MICs and MBCs of nalidixic acid, norfloxacin, ciprofloxacin, ofloxacin, pefloxacin and fleroxacin were determined for the strains using the methodology recommended by the NCCLS. Both strains were resistant to all the quinolones tested. Since long-term treatment with quinolones might favour the emergence of quinolone resistance or colonization with quinolone-resistant organisms, it is important to monitor for the development of bacterial resistance during therapy with the new fluoroquinolones.
从一名43岁糖尿病患者感染的希克曼导管中分离出对氟喹诺酮耐药的大肠埃希菌和肺炎克雷伯菌，该患者此前接受了为期24天的环丙沙星（200 mg/12 h静脉注射）治疗。使用美国国家临床实验室标准委员会（NCCLS）推荐的方法测定了这些菌株对萘啶酸、诺氟沙星、环丙沙星、氧氟沙星、培氟沙星和氟罗沙星的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。这两种菌株对所有测试的喹诺酮类药物均耐药。由于喹诺酮类药物的长期治疗可能有利于喹诺酮耐药性的出现或喹诺酮耐药菌的定植，因此在使用新型氟喹诺酮类药物治疗期间监测细菌耐药性的发展很重要。
