Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany.
J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1339-1346. doi: 10.1002/jcsm.12479. Epub 2019 Aug 21.
A poor fat-soluble micronutrient (FMN) and a high oxidative stress status are associated with frailty. Our aim was to determine the cross-sectional association of FMNs and oxidative stress biomarkers [protein carbonyls (PrCarb) and 3-nitrotyrosine] with the frailty status in participants older than 65 years.
Plasma levels of vitamins A (retinol), D , E (α-tocopherol and γ-tocopherol) and carotenoids (α-carotene and β-carotene, lycopene, lutein/zeaxanthin, and β-cryptoxanthin), PrCarb, and 3-nitrotyrosine were measured in 1450 individuals of the FRAILOMIC initiative. Participants were classified into robust, pre-frail, and frail using Fried's frailty criteria. Associations between biomarkers and frailty status were assessed by general linear and logistic regression models, both adjusted for cohort, season of blood sampling, gender, age, height, weight, and smoking.
Robust participants had significantly higher vitamin D and lutein/zeaxanthin concentrations than pre-frail and frail subjects; had significantly higher γ-tocopherol, α-carotene, β-carotene, lycopene, and β-cryptoxanthin concentrations than frail subjects, and had significantly lower PrCarb concentrations than frail participants in multivariate linear models. Frail subjects were more likely to be in the lowest than in the highest tertile for vitamin D (adjusted odds ratio: 2.15; 95% confidence interval: 1.42-3.26), α-tocopherol (2.12; 1.39-3.24), α-carotene (1.69; 1.00-2.88), β-carotene (1.84; 1.13-2.99), lycopene (1.94; 1.24-3.05), lutein/zeaxanthin (3.60; 2.34-5.53), and β-cryptoxanthin (3.02; 1.95-4.69) and were more likely to be in the highest than in the lowest tertile for PrCarb (2.86; 1.82-4.49) than robust subjects in multivariate regression models.
Our study indicates that both low FMN and high PrCarb concentrations are associated with pre-frailty and frailty.
脂溶性微量营养素（FMN）不足和氧化应激状态高与虚弱有关。我们的目的是确定血浆 FMN 和氧化应激生物标志物[蛋白羰基（PrCarb）和 3-硝基酪氨酸]与 65 岁以上参与者虚弱状态的横断面关联。
在 FRAILOMIC 研究中，对 1450 名个体的血浆维生素 A（视黄醇）、D、E（α-生育酚和γ-生育酚）和类胡萝卜素（α-胡萝卜素和β-胡萝卜素、番茄红素、叶黄素/玉米黄质和β-隐黄质）、PrCarb 和 3-硝基酪氨酸水平进行了测量。使用 Fried 的虚弱标准将参与者分为强壮、虚弱前期和虚弱。使用一般线性和逻辑回归模型评估生物标志物与虚弱状态之间的关联，两者均根据队列、采血季节、性别、年龄、身高、体重和吸烟情况进行调整。
与虚弱前期和虚弱组相比，强壮组的维生素 D 和叶黄素/玉米黄质浓度显著较高；与虚弱组相比，γ-生育酚、α-胡萝卜素、β-胡萝卜素、番茄红素和β-隐黄质浓度显著较高，PrCarb 浓度显著较低。在多元线性模型中。与处于最高三分位的参与者相比，虚弱组更有可能处于维生素 D（调整后的优势比：2.15；95%置信区间：1.42-3.26）、α-生育酚（2.12；1.39-3.24）、α-胡萝卜素（1.69；1.00-2.88）、β-胡萝卜素（1.84；1.13-2.99）、番茄红素（1.94；1.24-3.05）、叶黄素/玉米黄质（3.60；2.34-5.53）和β-隐黄质（3.02；1.95-4.69）的最低三分位，而在多元回归模型中，PrCarb（2.86；1.82-4.49）的最高三分位比强壮组更有可能处于最高三分位。
我们的研究表明，低 FMN 和高 PrCarb 浓度均与虚弱前期和虚弱有关。
