Department of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda.
Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Am J Trop Med Hyg. 2019 Oct;101(4):799-802. doi: 10.4269/ajtmh.19-0081.
We explored spatial variation in the prevalence of established molecular markers of antimalarial resistance across a geographically diverse, highland region of western Uganda. We identified CQ resistance transporter 76T mutations in all pools, but there was no evidence of spatial differences across village-based strata defined by either altitude or river valley. In contrast, we identified a significant inverse association between altitude and the prevalence of multidrug resistance 1 mutations with the largest proportion of Y184F mutations observed in the low-elevation, high-transmission villages. These results demonstrate the substantial heterogeneity in resistance markers observed across geographic settings, even at relatively small scales, but highlight the complex nature of these ecological relationships.
我们探索了在乌干达西部一个地理上多样化的高海拔地区，已确立的抗疟药物耐药性分子标记物的流行情况在空间上的变化。我们在所有样本中都发现了 CQ 耐药转运体 76T 突变，但没有证据表明在以海拔或河谷为基础的村庄层次上存在空间差异。相比之下，我们发现海拔高度与多药耐药 1 突变的流行率之间存在显著的反比关系，在低海拔、高传播的村庄中观察到最大比例的 Y184F 突变。这些结果表明，即使在相对较小的范围内，在地理环境中观察到的耐药标记物也存在很大的异质性，但也突出了这些生态关系的复杂性。
