Koziner B, Cosimi A B, Bloch K J
J Natl Cancer Inst. 1975 Dec;55(6):1295-9. doi: 10.1093/jnci/55.6.1295.
The distribution among peripheral blood mononuclear cells of latex-ingesting cells, T cells, and B cells was determined with samples from 38 normal donors and 25 patients with malignant melanoma. The mean percentage of latex-ingesting cells, as well as B and T cells, was significantly reduced in the 25 patients with malignant melanoma, stages I and II, compared to the controls. Several explanations for these unexpected findings were considered; possibly the presence of occult neoplasm was responsible for the observed changes in cell distribution.
通过38名正常供体和25名恶性黑色素瘤患者的样本，测定了摄取乳胶细胞、T细胞和B细胞在外周血单个核细胞中的分布情况。与对照组相比，I期和II期的25名恶性黑色素瘤患者中，摄取乳胶细胞以及B细胞和T细胞的平均百分比显著降低。对这些意外发现有几种解释；可能隐匿性肿瘤的存在是观察到的细胞分布变化的原因。
