Takahashi A, Nakamura H, Ikeda D, Naganawa H, Kameyama T, Kurasawa S, Okami Y, Takeuchi T, Iitaka Y
Institute of Microbial Chemistry, Tokyo, Japan.
J Antibiot (Tokyo). 1988 Nov;41(11):1568-74. doi: 10.7164/antibiotics.41.1568.
A new antitumor antibiotic thrazarine was soluble in water and positive to anisaldehyde-sulfuric acid and ninhydrin color reactions. The absolute structure of thrazarine was determined to be O-[3R)-2-diazo-3-hydroxybutyryl)-L-serine by acid hydrolysis, spectroscopic analysis and X-ray crystallographic analysis. Structurally, thrazarine was a new member of azaserine group antibiotics.
一种新型抗肿瘤抗生素噻嗪啉可溶于水，对茴香醛 - 硫酸和茚三酮显色反应呈阳性。通过酸水解、光谱分析和X射线晶体学分析确定噻嗪啉的绝对结构为O - [(3R)-2 - 重氮 - 3 - 羟基丁酰基] - L - 丝氨酸。从结构上看，噻嗪啉是氮杂丝氨酸类抗生素的一个新成员。
