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巴古胺A和B,由环状芽孢杆菌菌株产生的新型核苷类抗生素。II. 物理化学性质及结构测定

Bagougeramines A and B, new nucleoside antibiotics produced by a strain of Bacillus circulans. II. Physico-chemical properties and structure determination.

作者信息

Takahashi A, Ikeda D, Naganawa H, Okami Y, Umezawa H

出版信息

J Antibiot (Tokyo). 1986 Aug;39(8):1041-6. doi: 10.7164/antibiotics.39.1041.

DOI:10.7164/antibiotics.39.1041
PMID:3759654
Abstract

Bagougeramines A and B obtained as sulfates were soluble in water and positive to Sakaguchi, chlorine-tolidine and ninhydrin color reactions. Their structures were determined by acid hydrolysis and spectroscopic analysis. Structurally they were closely related to gougerotin and they contained the guanidino-D-alanine instead of the serine residue in gougerotin. Bagougeramine B had the spermidine instead of the 6'-NH2 in structure of bagougeramine A.

摘要

以硫酸盐形式获得的巴古格胺A和B可溶于水,对坂口反应、氯代联苯胺反应和茚三酮显色反应呈阳性。它们的结构通过酸水解和光谱分析确定。从结构上看,它们与谷氏菌素密切相关,并且它们含有胍基-D-丙氨酸,而不是谷氏菌素中的丝氨酸残基。巴古格胺B在结构上具有亚精胺,而不是巴古格胺A结构中的6'-NH2。

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J Antibiot (Tokyo). 1986 Aug;39(8):1041-6. doi: 10.7164/antibiotics.39.1041.
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