不同特异性的人单克隆自身抗体对重链可变区亚组的独特使用模式。
Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity.
作者信息
Silverman G J, Goñi F, Fernandez J, Chen P P, Frangione B, Carson D A
机构信息
Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037.
出版信息
J Exp Med. 1988 Dec 1;168(6):2361-6. doi: 10.1084/jem.168.6.2361.
Abstract
Using a panel of antibodies specific for H and L chain variable region subgroups, a panel of human monoclonal cold agglutinin (CA) and rheumatoid factor (RF) autoantibodies were analyzed. The vast majority of the two types of autoantibodies utilized VkIII L chains, many of which probably derive from the Humkv325 gene. However, while most RFs (77%) utilized VHI H chains, all the CAs used VHII subgroup H chains. These results are consistent with a model of autoantibody generation, wherein binding specificity is H chain defined in a set of antibodies that use a multipotential L chain.
摘要
利用一组针对重链和轻链可变区亚组的抗体，对一组人单克隆冷凝集素（CA）和类风湿因子（RF）自身抗体进行了分析。这两种自身抗体绝大多数使用VkIII轻链，其中许多可能源自Humkv325基因。然而，虽然大多数RF（77%）使用VHI重链，但所有CA都使用VHII亚组重链。这些结果与自身抗体产生模型一致，即在一组使用多能轻链的抗体中，结合特异性由重链定义。
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