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1
Human rheumatoid factor crossidiotypes. II. Primary structure-dependent crossreactive idiotype, PSL2-CRI, present on Wa monoclonal rheumatoid factors is present on Bla and other IgM kappa monoclonal autoantibodies.人类风湿因子交叉独特型。II. 存在于Wa单克隆类风湿因子上的依赖一级结构的交叉反应独特型PSL2-CRI，也存在于Bla和其他IgM κ单克隆自身抗体上。
J Exp Med. 1987 Jan 1;165(1):263-7. doi: 10.1084/jem.165.1.263.
2
Human rheumatoid factor crossidiotypes. I. WA and BLA are heat-labile conformational antigens requiring both heavy and light chains.人类风湿因子交叉独特型。I. WA和BLA是热不稳定的构象抗原，重链和轻链均不可或缺。
J Exp Med. 1986 Nov 1;164(5):1809-14. doi: 10.1084/jem.164.5.1809.
3
The majority of human monoclonal IgM rheumatoid factors express a "primary structure-dependent" cross-reactive idiotype.大多数人源单克隆IgM类风湿因子表达一种“一级结构依赖性”交叉反应独特型。
J Immunol. 1985 May;134(5):3281-5.
4
Human rheumatoid factor cross-idiotypes. IV. Studies on WA XId-positive IgM without rheumatoid factor activity provide evidence that the WA XId is not unique to rheumatoid factors and is distinct from the 17.109 and G6 XIds.人类风湿因子交叉独特型。IV. 对无类风湿因子活性的WA XId阳性IgM的研究表明，WA XId并非类风湿因子所特有，且与17.109和G6 XIds不同。
J Exp Med. 1993 Dec 1;178(6):1903-11. doi: 10.1084/jem.178.6.1903.
5
Human rheumatoid factor cross-idiotypes. III. Bla monoclonal rheumatoid factor, prototype of the BLA cross-idiotype group, has distinct kappa chains related to the V kappa III subgroup and VH4 heavy chains.人类风湿因子交叉独特型。III. Bla单克隆类风湿因子，BLA交叉独特型组的原型，具有与VκIII亚组相关的独特κ链和VH4重链。
Arthritis Rheum. 1990 Nov;33(11):1710-5. doi: 10.1002/art.1780331115.
6
Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide.用人抗合成肽抗体描绘人自身抗体上的交叉反应独特型。
J Exp Med. 1984 May 1;159(5):1502-11. doi: 10.1084/jem.159.5.1502.
7
Expression of three cross-reactive idiotypes on rheumatoid factor autoantibodies from patients with autoimmune diseases and seropositive adults.自身免疫性疾病患者和血清反应阳性成年人类风湿因子自身抗体上三种交叉反应性独特型的表达
J Immunol. 1986 Jul 1;137(1):122-8.
8
Idiotypic characteristics of rheumatoid factors.类风湿因子的独特型特征。
Scand J Rheumatol Suppl. 1988;75:58-65. doi: 10.3109/03009748809096742.
9
Structural similarities in the kappa light chains of human rheumatoid factor paraproteins and serum immunoglobulins bearing a cross-reactive idiotype.人类类风湿因子副蛋白和带有交叉反应性独特型的血清免疫球蛋白κ轻链的结构相似性。
J Immunol. 1985 Sep;135(3):1955-60.
10
Sequence similarities and cross-idiotypic specificity of L chains among human monoclonal IgM kappa with anti-gamma-globulin activity.具有抗γ球蛋白活性的人单克隆IgM κ轻链之间的序列相似性和交叉独特型特异性。
J Immunol. 1985 Dec;135(6):4073-9.

引用本文的文献

1
Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity.不同特异性的人单克隆自身抗体对重链可变区亚组的独特使用模式。
J Exp Med. 1988 Dec 1;168(6):2361-6. doi: 10.1084/jem.168.6.2361.
2
Idiotypes and the structural diversity of human rheumatoid factors.独特型与人类类风湿因子的结构多样性
Springer Semin Immunopathol. 1988;10(2-3):189-201. doi: 10.1007/BF01857224.
3
Cross-reacting idiotypes on cryoprecipitating rheumatoid factor.冷沉淀类风湿因子上的交叉反应独特型
Springer Semin Immunopathol. 1988;10(1):35-55. doi: 10.1007/BF02054022.
4
Idiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans.人单克隆类风湿因子的独特型及亚组分析。对人类自身抗体结构和遗传基础的启示。
J Clin Invest. 1988 Aug;82(2):469-75. doi: 10.1172/JCI113620.
5
Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.自身抗体相关的κ轻链可变区基因在体细胞突变很少或没有体细胞突变的慢性淋巴细胞白血病中表达。对病因学和免疫治疗的意义。
J Exp Med. 1988 Mar 1;167(3):840-52. doi: 10.1084/jem.167.3.840.
6
Rheumatoid factor cross idiotypes.类风湿因子交叉独特型。
Springer Semin Immunopathol. 1988;10(2-3):203-14. doi: 10.1007/BF01857225.
7
The kidney in mixed cryoglobulinemias.混合性冷球蛋白血症中的肾脏。
Springer Semin Immunopathol. 1987;9(4):395-415. doi: 10.1007/BF00197217.
8
Expression of a public idiotype by human monoclonal IgM directed to myelin-associated glycoprotein and characterization of the variability subgroup of their heavy and light chains.针对髓鞘相关糖蛋白的人单克隆IgM的公共独特型表达及其重链和轻链可变亚组的特征分析
J Exp Med. 1989 Nov 1;170(5):1551-8. doi: 10.1084/jem.170.5.1551.
9
Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family.一种人类抗巨细胞病毒抗体克隆重链和轻链可变区的完整蛋白质序列，与Wa独特型家族的人类单克隆类风湿因子显示出惊人的相似性。
J Clin Invest. 1988 May;81(5):1511-8. doi: 10.1172/JCI113483.

本文引用的文献

1
VK IIIb expression is altered in acquired and drug-induced hypogammaglobulinaemia.VK IIIb表达在获得性和药物诱导的低丙种球蛋白血症中发生改变。
Immunology. 1984 Dec;53(4):779-82.
2
Sequence similarities among kappa IIIb chains of monoclonal human IgM kappa autoantibodies.单克隆人IgMκ自身抗体的κIIIb链之间的序列相似性。
J Exp Med. 1984 Sep 1;160(3):893-904. doi: 10.1084/jem.160.3.893.
3
Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide.用人抗合成肽抗体描绘人自身抗体上的交叉反应独特型。
J Exp Med. 1984 May 1;159(5):1502-11. doi: 10.1084/jem.159.5.1502.
4
Evidence for a subset of rheumatoid factors that cross-react with DNA-histone and have a distinct cross-idiotype.与DNA-组蛋白发生交叉反应且具有独特交叉独特型的类风湿因子亚群的证据。
J Exp Med. 1980 Jun 1;151(6):1514-27. doi: 10.1084/jem.151.6.1514.
5
Light chain sequences of human IgM cold agglutinins (variable-region subgroups amino-acid sequence-kappa light chain-N-terminal).人IgM冷凝集素的轻链序列（可变区亚组氨基酸序列-κ轻链- N端）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):40-3. doi: 10.1073/pnas.69.1.40.
6
Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity.具有抗球蛋白活性的单克隆IgM蛋白之间的交叉独特型特异性。
J Exp Med. 1973 Feb 1;137(2):331-42. doi: 10.1084/jem.137.2.331.
7
The majority of human monoclonal IgM rheumatoid factors express a "primary structure-dependent" cross-reactive idiotype.大多数人源单克隆IgM类风湿因子表达一种“一级结构依赖性”交叉反应独特型。
J Immunol. 1985 May;134(5):3281-5.
8
The VKIIIb light chain sub-subgroup: restricted association with mu heavy chain in normal human serum.VκIIIb轻链亚亚组：在正常人血清中与μ重链的限制性关联。
Immunology. 1985 Feb;54(2):207-13.
9
Human rheumatoid factor crossidiotypes. I. WA and BLA are heat-labile conformational antigens requiring both heavy and light chains.人类风湿因子交叉独特型。I. WA和BLA是热不稳定的构象抗原，重链和轻链均不可或缺。
J Exp Med. 1986 Nov 1;164(5):1809-14. doi: 10.1084/jem.164.5.1809.
10
Expression of three cross-reactive idiotypes on rheumatoid factor autoantibodies from patients with autoimmune diseases and seropositive adults.自身免疫性疾病患者和血清反应阳性成年人类风湿因子自身抗体上三种交叉反应性独特型的表达
J Immunol. 1986 Jul 1;137(1):122-8.

人类风湿因子交叉独特型。II. 存在于Wa单克隆类风湿因子上的依赖一级结构的交叉反应独特型PSL2-CRI，也存在于Bla和其他IgM κ单克隆自身抗体上。

Human rheumatoid factor crossidiotypes. II. Primary structure-dependent crossreactive idiotype, PSL2-CRI, present on Wa monoclonal rheumatoid factors is present on Bla and other IgM kappa monoclonal autoantibodies.

作者信息

Agnello V, Goñi F, Barnes J L, de la Vega M T, Frangione B

出版信息

J Exp Med. 1987 Jan 1;165(1):263-7. doi: 10.1084/jem.165.1.263.

DOI:10.1084/jem.165.1.263
PMID:3098895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188267/
Abstract

The amino acid sequence of the L-CDR2 (complementarity-determining region) of Bla mRF (monoclonal rheumatoid factor) is identical to that of the Wa mRFs. The PSL2-CRI (crossreactive idiotype), as determined by anti-PSL2, which has been shown to be present on all Wa mRFs, is also present on the Bla mRF and other monoclonal autoantibodies. PSL2-CRI is, therefore, not unique to Wa mRFs and may be present on most IgM kappa monoclonal autoantibodies. Whether PSL2-CRI is a crossidiotype (XId) that is selectively present on autoantibodies or represents an allotypic marker for a V kappa III gene is undetermined.

摘要

Bla mRF（单克隆类风湿因子）的L-CDR2（互补决定区）氨基酸序列与Wa mRFs的相同。由抗PSL2确定的PSL2-CRI（交叉反应独特型）已证存在于所有Wa mRFs上，也存在于Bla mRF和其他单克隆自身抗体上。因此，PSL2-CRI并非Wa mRFs所特有，可能存在于大多数IgM κ单克隆自身抗体上。PSL2-CRI是选择性存在于自身抗体上的交叉独特型（XId）还是代表V κ III基因的同种异型标记尚不确定。