埃塞俄比亚梅毒流行病学：一项涵盖过去三十年的系统评价和荟萃分析研究方案。
The epidemiology of syphilis in Ethiopia: a protocol for systematic review and meta-analysis covering the last three decades.
机构信息
Department of Public Health, College of Health Sciences, Mizan-Tepi University, Tepi, Ethiopia.
Department of Medical Laboratory Sciences, College of Health Sciences, Mizan-Tepi University, Tepi, Ethiopia.
出版信息
Syst Rev. 2019 Aug 22;8(1):210. doi: 10.1186/s13643-019-1136-z.
BACKGROUND
Several individual epidemiological studies in Ethiopia suggest that syphilis is a public health problem. However, to the best of our knowledge, there is no synthesized and meta-analysis data on the epidemiology of syphilis in Ethiopia. This systematic review and meta-analysis aimed to summarize and synthesize existing data on the prevalence of syphilis in Ethiopia.
METHOD
Studies reporting the prevalence of syphilis will be identified from major databases and gray literature. The major databases (MEDLINE/PubMed, EMBASE, Web of Science, CINAHL, The Cochrane Library, Lilacs, and African journal online) and gray literature (Google Scholar search engine, official WHO and CDC websites, the online library of academic and governmental institutions in Ethiopia) will be searched. Studies published/reported from 1 January 1990 to 1 January 2019 will be included to have a contemporary estimation. A random-effect meta-analysis of prevalence will be used after stabilizing the variance of included studies using a single arc transformation. The quality of the included studies will be assessed using the Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instruments. Heterogeneity and publication bias will be assessed. If significant heterogeneity is detected, subgroup analysis will be done using study region, study population, diagnostic assay/syphilis screening tool, median sample size, year of data collection, study sites, sampling method, and methodological quality as grouping variables.
DISCUSSION
This systematic review and meta-analysis intend to contribute an improved knowledge on the epidemiology of syphilis in Ethiopia. Knowledge about the epidemiology of syphilis may help policymakers and other stakeholders to allocate resources and target interventions for the prevention and elimination of syphilis.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42018116231.
背景
埃塞俄比亚的几项个体流行病学研究表明梅毒是一个公共卫生问题。然而，据我们所知，尚无关于埃塞俄比亚梅毒流行病学的综合和荟萃分析数据。本系统评价和荟萃分析旨在总结和综合现有关于埃塞俄比亚梅毒患病率的数据。
方法
将从主要数据库和灰色文献中确定报告梅毒患病率的研究。主要数据库（MEDLINE/PubMed、EMBASE、Web of Science、CINAHL、The Cochrane Library、Lilacs 和 African journal online）和灰色文献（Google Scholar 搜索引擎、世界卫生组织和疾病预防控制中心官方网站、埃塞俄比亚学术和政府机构的在线图书馆）将被搜索。将纳入 1990 年 1 月 1 日至 2019 年 1 月 1 日发表/报告的研究，以进行当代估计。使用单弧变换稳定纳入研究的方差后，将采用随机效应荟萃分析进行患病率分析。使用 Joanna Briggs 研究所 Meta 分析统计评估和审查工具评估纳入研究的质量。将评估异质性和发表偏倚。如果检测到显著的异质性，将使用研究区域、研究人群、诊断检测/梅毒筛查工具、中位数样本量、数据收集年份、研究地点、抽样方法和方法学质量等分组变量进行亚组分析。
讨论
本系统评价和荟萃分析旨在为了解埃塞俄比亚梅毒流行病学提供更多的知识。关于梅毒流行病学的知识可以帮助政策制定者和其他利益相关者分配资源并针对梅毒的预防和消除目标干预措施。
系统评价注册
PROSPERO CRD42018116231。
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