RNA 聚合酶 II 延伸因子的研究历程：历史回顾。
The hunt for RNA polymerase II elongation factors: a historical perspective.
机构信息
Stowers Institute for Medical Research, Kansas City, MO, USA.
Department of Biochemistry & Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA.
出版信息
Nat Struct Mol Biol. 2019 Sep;26(9):771-776. doi: 10.1038/s41594-019-0283-1. Epub 2019 Aug 22.
PMID:31439940
Abstract
The discovery of the three eukaryotic nuclear RNA polymerases paved the way for serious biochemical investigations of eukaryotic transcription and the identification of eukaryotic transcription factors. Here we describe this adventure from our vantage point, with a focus on the hunt for factors that regulate elongation by RNA polymerase II.
摘要
真核生物三种核 RNA 聚合酶的发现为真核生物转录的深入生化研究和真核生物转录因子的鉴定铺平了道路。在这里，我们从有利位置描述了这段历程，重点是寻找调节 RNA 聚合酶 II 延伸的因子。
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