Bláfoss Joan, Hansen Anne Vejen, Malchau Lauesgaard Sara S, Ali Zarqa, Ulrik Charlotte Suppli
Department of Respiratory Medicine, Hvidovre Hospital, Hvidovre, Denmark.
Department of Gynaecology and Obstetrics, Hvidovre Hospital, Hvidovre, Denmark.
J Asthma Allergy. 2019 Jul 24;12:205-211. doi: 10.2147/JAA.S203576. eCollection 2019.
Asthma is one of the most common chronic diseases among women of reproductive age, and previous studies have suggested a link between female asthma and infertility. The aim of the present review is to provide an update on current knowledge of the association between female asthma and/or atopy and a reduction in fertility, ie, number of offspring, time to pregnancy (TTP) and need for fertility treatment.
Systematic review performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-guidelines.
A total of 14 studies fulfilled the predefined criteria for inclusion in the present review. Six studies investigated the association between female asthma and/or atopy and number of offspring, of which one reported a positive, two a negative, and three no association. Three studies addressed the association between asthma and TTP and found that TTP was significantly prolonged in asthmatic women compared to non-asthmatic women. Five studies investigated subfertility and the need for fertility treatments of which two studies found a higher prevalence of infertility among women prescribed anti-asthma medication. One study found no difference in the number of fertility treatments of asthmatic women compared to non-asthmatic women, whereas three studies reported that female asthma was associated with significantly more fertility treatment compared to non-asthmatic women.
Although the available evidence is conflicting, there is a clear trend toward an association between female asthma and a reduction in fertility, and by that a larger proportion requiring fertility treatment, even though female asthma might not negatively affect total number of offspring.
哮喘是育龄女性中最常见的慢性病之一，既往研究提示女性哮喘与不孕之间存在关联。本综述的目的是更新关于女性哮喘和/或特应性与生育力降低（即后代数量、受孕时间（TTP）和生育治疗需求）之间关联的现有知识。
按照系统评价与Meta分析的首选报告项目指南进行系统评价。
共有14项研究符合本综述纳入的预定标准。6项研究调查了女性哮喘和/或特应性与后代数量之间的关联，其中1项报告为正相关，2项为负相关，3项无关联。3项研究探讨了哮喘与TTP之间的关联，发现哮喘女性的TTP显著长于非哮喘女性。5项研究调查了生育力低下和生育治疗需求，其中2项研究发现，使用抗哮喘药物的女性中不孕患病率更高。1项研究发现哮喘女性与非哮喘女性在生育治疗次数上无差异，而3项研究报告称，与非哮喘女性相比，女性哮喘与显著更多的生育治疗相关。
尽管现有证据相互矛盾，但女性哮喘与生育力降低之间存在关联的趋势明显，因此需要生育治疗的比例更大，尽管女性哮喘可能不会对后代总数产生负面影响。
