Department of Internal Medicine and Allergy, Immunology, Adana City Education and Research Hospital, Turkey, Adana.
Department of Chest Medicine, Adana City Education and Research Hospital, Adana, Turkey.
Ann Med. 2021 Dec;53(1):456-458. doi: 10.1080/07853890.2021.1900591.
İNTRODUCTION: Asthma is one of the most common chronic airway disease among reproductive period of women. Chronic inflammation in asthma, eosinophilia, high steroid treatment and uncontrolled asthma may cause infertility by affecting the reproductive organs, menstrual cycle and quality of life. Some patients with severe asthma have frequent exacerbations associated with persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled glucocorticoids with or without oral glucocorticoids. Mepolizumab (anti-IL-5) is a succesful option of treatment.
First case; 25-year-old female patient has been diagnosed having asthma and rhinitis for 5 years. Even she had desired pregnancy for 3 years, she was unable to have a baby, and had been diagnosed having primary infertility. Second case; 36 years old female had rhinitis for 6 years and asthma for 4 years Although she used the same contraception method (withdrawal,condom) for years, she did not get pregnant until receiving the second dose of mepolizumab treatment.
Two women were treated with mepolizumab for eosinophilic severe asthma and they got pregnant.
Unexplained infertility in people with severe eosinophilic asthma may be corrected by mepolizumab treatment. However, there is not enough data regarding the use of mepolizumab during pregnancy.
哮喘是女性生育期最常见的慢性气道疾病之一。哮喘的慢性炎症、嗜酸性粒细胞增多、高剂量类固醇治疗和未控制的哮喘可能通过影响生殖器官、月经周期和生活质量导致不孕。一些严重哮喘患者尽管持续使用高剂量吸入性糖皮质激素联合或不联合口服糖皮质激素治疗，但仍频繁发生与持续嗜酸性粒细胞炎症相关的加重。美泊利珠单抗（抗 IL-5）是一种成功的治疗选择。
第一个病例：一名 25 岁的女性患者，患有哮喘和鼻炎 5 年。尽管她已经有 3 年的生育愿望，但一直未能怀孕，被诊断为原发性不孕。第二个病例：一名 36 岁的女性，患有鼻炎 6 年，哮喘 4 年。尽管她多年来一直使用相同的避孕方法（撤退法、避孕套），但在接受第二剂美泊利珠单抗治疗后才怀孕。
两名患有严重嗜酸性粒细胞性哮喘的女性接受了美泊利珠单抗治疗，随后怀孕。
对于患有严重嗜酸性粒细胞性哮喘的不明原因不孕患者，美泊利珠单抗治疗可能会得到纠正。然而，关于怀孕期间使用美泊利珠单抗的数据还不够充分。
