糖尿病患者与非糖尿病患者行胆胰分流术后血清镁水平的差异。

Differences in Serum Magnesium Levels in Diabetic and Non-Diabetic Patients Following One-Anastomosis Gastric Bypass.

机构信息

Department of Social and Preventive Medicine, Centre for Public Health, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.

Department of Medicine 1 and Karl Landsteiner Institute for Obesity and Metabolic Disorders, Rudolfstiftung Hospital, Juchgasse 25, 1030 Vienna, Austria.

出版信息

Nutrients. 2019 Aug 22;11(9):1984. doi: 10.3390/nu11091984.

DOI:10.3390/nu11091984

PMID:31443510

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6770951/

Abstract

Patients with obesity and type 2 diabetes mellitus (T2DM) are regarded to have reduced serum magnesium (Mg) concentrations. We aimed to assess the changes in serum Mg concentrations at 12-month follow-up in patients, with and without T2DM, who underwent one anastomosis gastric bypass surgery. Overall, 50 patients (80% female, age 42.2 (12.5) years) with morbid obesity (mean baseline BMI 43.8 (4.3) kg/m2) were included in the analysis. Half of the included patients had T2DM diagnosed at baseline, and these patients showed lower serum Mg concentration (0.78 (0.07)) vs. 0.83 (0.05) mmol/L; = 0.006), higher blood glucose levels (129.9 (41.3) vs. 87.6 (8.1) mg/dL; < 0.001) as well as HbA1c concentrations (6.7 (1.4) vs. 5.3 (0.5)%; < 0.001). During follow-up, BMI and glucose levels showed a decrease; however, serum Mg levels remained stable. At baseline 42% of patients were found to be Mg deficient, which was reduced to 33% at six months and to 30% at 12 months follow-up. Moreover, patients with T2DM had an odds ratio of 9.5 (95% CI = 3.0-29.7; < 0.001) for magnesium deficiency when compared to patients without T2DM. Further research into the role of Mg and its role in T2DM and other obesity-related comorbidities are needed.

摘要

患有肥胖症和 2 型糖尿病（T2DM）的患者被认为血清镁（Mg）浓度降低。我们旨在评估接受单吻合胃旁路手术的肥胖症患者和 T2DM 患者在 12 个月随访时血清 Mg 浓度的变化。总体而言，有 50 名患者（80%为女性，年龄 42.2（12.5）岁）患有病态肥胖症（基线平均 BMI 为 43.8（4.3）kg/m2）被纳入分析。所纳入患者的一半在基线时被诊断为 T2DM，这些患者的血清 Mg 浓度较低（0.78（0.07）vs. 0.83（0.05）mmol/L；=0.006），血糖水平较高（129.9（41.3）vs. 87.6（8.1）mg/dL；<0.001）和 HbA1c 浓度（6.7（1.4）vs. 5.3（0.5）%；<0.001）。在随访期间，BMI 和血糖水平下降，但血清 Mg 水平保持稳定。在基线时，有 42%的患者被发现存在 Mg 缺乏症，6 个月时减少至 33%，12 个月时减少至 30%。此外，与无 T2DM 的患者相比，患有 T2DM 的患者出现 Mg 缺乏症的几率为 9.5（95%CI=3.0-29.7；<0.001）。需要进一步研究 Mg 的作用及其在 T2DM 和其他肥胖相关合并症中的作用。