State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Allergol Int. 2020 Jan;69(1):35-45. doi: 10.1016/j.alit.2019.08.001. Epub 2019 Aug 21.
Allergic diseases, which include asthma, allergic skin diseases, allergic rhinitis and allergic conjunctivitis, have already garnered worldwide public health attention over recent decades. Mesenchymal stem cells (MSCs) have gradually emerged as a potential method for treating allergic diseases due to their immunosuppressive characteristics, tissue repair ability and secretion of various biological factors. This potential of MSC-based therapy has been confirmed in clinical and preclinical studies, which report the therapeutic benefits of MSCs for various allergic diseases and explore the antiallergic mechanisms. In this review, we focus on the discoveries and biological mechanisms of MSCs as a therapeutic tool in allergic diseases. We discuss the challenges of conducting MSC studies as well as future directions.
过敏疾病，包括哮喘、过敏性皮肤病、过敏性鼻炎和过敏性结膜炎，近几十年来已经引起了全球公共卫生的关注。间充质干细胞（MSCs）由于其免疫抑制特性、组织修复能力和分泌各种生物因子，逐渐成为治疗过敏疾病的一种潜在方法。基于 MSC 的治疗的这种潜力已经在临床和临床前研究中得到证实，这些研究报告了 MSCs 对各种过敏疾病的治疗益处，并探讨了抗过敏机制。在这篇综述中，我们专注于 MSCs 作为治疗过敏疾病的治疗工具的发现和生物学机制。我们讨论了进行 MSC 研究的挑战以及未来的方向。
