Morawska-Kozłowska Magdalena, Pitas Mateusz, Zhalniarovich Yauheni
Department of Surgery and Radiology with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
Veterinary Polyclinic, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
Animals (Basel). 2025 Apr 19;15(8):1175. doi: 10.3390/ani15081175.
Mesenchymal stem cells (MSCs) hold significant therapeutic potential in veterinary medicine due to their regenerative and immunomodulatory properties. This review examines the clinical applications of MSCs across multiple animal species, including equine, canine, feline, and bovine medicine. MSC therapies have demonstrated promising outcomes in treating musculoskeletal disorders, osteoarthritis, inflammatory diseases, and tissue injuries, particularly in horses and dogs. In cats, MSCs show potential for managing chronic kidney disease, inflammatory bowel disease, and asthma, while in bovine medicine, they offer alternative treatment approaches for mastitis and orthopedic injuries. Despite these advancements, challenges such as treatment standardization, cell sourcing, and potential adverse effects, including tumorigenicity, remain under investigation. The emerging field of MSC-based veterinary medicine highlights its capacity to enhance healing, reduce inflammation, and improve clinical outcomes. However, further research is necessary to optimize treatment protocols and address safety concerns, ensuring the widespread adoption of MSC therapies in veterinary practice.
间充质干细胞（MSCs）因其再生和免疫调节特性在兽医学中具有巨大的治疗潜力。本综述探讨了MSCs在多种动物物种中的临床应用，包括马、犬、猫和牛医学。MSCs疗法在治疗肌肉骨骼疾病、骨关节炎、炎症性疾病和组织损伤方面已显示出有前景的结果，特别是在马和犬中。在猫中，MSCs在管理慢性肾病、炎症性肠病和哮喘方面显示出潜力，而在牛医学中，它们为乳腺炎和骨科损伤提供了替代治疗方法。尽管有这些进展，但诸如治疗标准化、细胞来源以及潜在的不良反应（包括致瘤性）等挑战仍在研究中。基于MSCs的兽医学这一新兴领域凸显了其促进愈合、减轻炎症和改善临床结果的能力。然而，需要进一步研究以优化治疗方案并解决安全问题，确保MSCs疗法在兽医实践中的广泛应用。
