Department of Orthopedics, The Second Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).
Med Sci Monit. 2019 Aug 25;25:6378-6382. doi: 10.12659/MSM.915559.
Osteosarcoma is a malignant tumor that occurs most commonly in the metaphysis of the long bones in the limbs in children and adolescents. Even with surgery and neoadjuvant chemotherapy, the therapeutic effect has reached a peak with 60-70% survival rates. Therefore, new biological targets or molecular mechanisms that enhance the efficacy of osteosarcoma treatments are needed. Circular RNAs (circRNAs) are useful biomarkers that have recently been recognized clinically and in medical research and have been of interest due to the use of next-generation sequencing and bioinformatics analysis. CircRNAs are involved in many diseases, including cancer. Therefore, this review aims to summarize the roles of circRNA in the diagnosis, progression, and prognosis of osteosarcoma.
骨肉瘤是一种恶性肿瘤，最常发生在儿童和青少年四肢长骨的干骺端。即使采用手术和新辅助化疗，其治疗效果也已达到高峰，生存率为 60-70%。因此，需要新的生物靶点或分子机制来提高骨肉瘤治疗的疗效。环状 RNA（circRNA）是最近在临床和医学研究中被认识到的有用的生物标志物，由于使用了下一代测序和生物信息学分析，因此受到了关注。circRNA 参与了许多疾病，包括癌症。因此，本综述旨在总结 circRNA 在骨肉瘤的诊断、进展和预后中的作用。
