Pavlov A V
Arkh Anat Gistol Embriol. 1988 Jul;95(7):51-4.
By means of cytometry estimation of mitotic index and nucleo-cytoplasmic relation of parathyrocytes, parathyroid glands have been studied in 52 white rats and 28 white mice under conditions of intal inhibition (30 mg/kg of body mass twice a day intraperitoneally) of tissue basophils (TB) secretory activity. For stimulation of the glands, repeated injections of trilon B and hemiparathyroidectomy are used. The experiment lasts for 3.5 days. In the rat parathyroid glands, containing a considerable amount of TB, intal does not produce any important effect of quantitative parameters of the organ's structure in intact animals, nevertheless it prevents development of hypertrophy of the parathyrocytes in the stimulated glands, as well as makes weaker the proliferative response of the cells to hemiparathyroidectomy. In mice, their parathyroid glands containing single TB, under conditions of stimulation of the parathyroid function, intal does not produce any inhibitory effect to growth of middle size parathyrocytes. The results obtained demonstrate that the parathyroid TB actively participate in regulation of the organ's morphofunctional state, intensifying the stimulating effect of hypocalcaemia to the parathyroid parenchyma.
通过细胞计数法评估甲状旁腺细胞的有丝分裂指数和核质关系，在52只白色大鼠和28只白色小鼠中，于组织嗜碱性粒细胞（TB）分泌活性受到英他洛尔抑制（每天腹腔注射两次，每次30mg/kg体重）的条件下，对甲状旁腺进行了研究。为刺激甲状旁腺，采用重复注射氨三乙酸B和半甲状旁腺切除术。实验持续3.5天。在含有大量TB的大鼠甲状旁腺中，英他洛尔对完整动物器官结构的定量参数未产生任何重要影响，然而，它可防止受刺激的甲状旁腺细胞肥大的发展，并使细胞对半甲状旁腺切除术的增殖反应减弱。在小鼠中，其甲状旁腺含有单个TB，在甲状旁腺功能受到刺激的情况下，英他洛尔对中等大小甲状旁腺细胞的生长未产生任何抑制作用。所获得的结果表明，甲状旁腺TB积极参与器官形态功能状态的调节，增强低钙血症对甲状旁腺实质的刺激作用。
