Keeley Tyler S, Yang Shengyu, Lau Eric
Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA.
University of South Florida Cancer Biology Graduate Program, Tampa, FL 33602, USA.
Cancers (Basel). 2019 Aug 24;11(9):1241. doi: 10.3390/cancers11091241.
Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O'- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling pathways. How L-fucose and serum fucosylation patterns might be used for future clinical diagnostic, prognostic, and therapeutic approaches will be discussed.
岩藻糖基化是聚糖、蛋白质和脂质的一种翻译后修饰，它参与许多生物学过程。岩藻糖通过α(1,2)、α(1,3)、α(1,4)、α(1,6)和O'-连接与聚糖结合，以及岩藻糖基化连接方式的变化，对癌症生物学具有重要意义。本综述重点关注岩藻糖基化在癌症中所起的作用，特别是通过调节细胞表面蛋白和信号通路来发挥作用。还将讨论L-岩藻糖和血清岩藻糖基化模式如何用于未来的临床诊断、预后评估和治疗方法。
