Curado Maria Paula, Silva Diego Rodrigues Mendonça E, Oliveira Max Moura de, Soares Fernando, Begnami Maria Dirlei, Coimbra Felipe José Fernandez, Assumpção Paulo Pimentel de, de Sant'Ana Rosane Oliveira, Demachki Samia, Dias-Neto Emmanuel
Epidemiology and Statistics Nucleus, International Research Center, A.C.Camargo Cancer Center, Sao Paulo, Brazil. Email:
Anatomic Pathology Department, Rede D'Or Hospitals, Sao Paulo, Brazil.
Asian Pac J Cancer Prev. 2019 Aug 1;20(8):2253-2258. doi: 10.31557/APJCP.2019.20.8.2253.
Background: Despite decreasing global incidence trends, gastric cancer is still among the five most incident cancers in the world and the third cancer-related cause of death. In Brazil, differences in incidence and mortality exist depending on the geographic region studied. Objective: To describe the incidence, mortality, trends and age-period-cohort of gastric cancer in three cities of Brazil (Sao Paulo, Belem and Fortaleza), in the period 1990-2012. Mortality for gastric cancer in Brazil overall and by region was described. Methods: 33,462 incident cases of gastric cancer were identified from the population-based cancer registries and 23,424 deaths from mortality information system in residents of the three cities and in Brazil were included in the study. Data for incident cases were extracted from the Population Based Cancer Registries from the National Cancer Institute (INCA). Mortality data on gastric cancer were extracted from Information Technology Department of Brazilian Public Health Care System/Health Ministry (DATASUS/MS). Mortality and incidence age standardized rates were calculated. For trends analysis the Joinpoint Regression and age-period-cohort model were applied. Results: Belem presented the highest incidence rates for gastric adenocarcinoma. Decreasing incidence trends were identified in Sao Paulo (-7.8% in men; -6.3% in women) and in Fortaleza (-1.2% in men). Increasing incidence trends were observed for women in Belem (1.8%) and Fortaleza (1.1%). In Belem (Amazon area), there was an increased risk for gastric cancer in women born after the 1960s. Overall in Brazil mortality for gastric cancer is decreasing. Mortality trends showed significant reduction, for both sexes, in the three Brazilian cities. Conclusion: Incidence of gastric cancer is increasing in women born in the sixties in Belem (Amazon region) and Fortaleza (Northeast region). In Brazil there was increase in mortality in Northeast region and decrease in others regions. More update data on incidence for Amazon and Northeast region is needed.
尽管全球发病率呈下降趋势，但胃癌仍是全球发病率最高的五种癌症之一，也是癌症相关死亡的第三大原因。在巴西，发病率和死亡率因所研究的地理区域而异。目的：描述1990 - 2012年巴西三个城市（圣保罗、贝伦和福塔莱萨）胃癌的发病率、死亡率、趋势以及年龄 - 时期 - 队列情况。描述了巴西总体及各地区的胃癌死亡率。方法：从基于人群的癌症登记处识别出33462例胃癌发病病例，并将来自三个城市及巴西居民死亡信息系统的23424例死亡病例纳入研究。发病病例数据从国家癌症研究所（INCA）的基于人群的癌症登记处提取。胃癌死亡率数据从巴西公共卫生保健系统/卫生部信息技术部（DATASUS/MS）提取。计算了死亡率和发病率的年龄标准化率。对于趋势分析，应用了Joinpoint回归和年龄 - 时期 - 队列模型。结果：贝伦的胃腺癌发病率最高。圣保罗（男性为 - 7.8%；女性为 - 6.3%）和福塔莱萨（男性为 - 1.2%）出现发病率下降趋势。贝伦（1.8%）和福塔莱萨（1.1%）的女性出现发病率上升趋势。在贝伦（亚马逊地区），20世纪60年代后出生的女性患胃癌的风险增加。巴西总体上胃癌死亡率在下降。三个巴西城市的男女死亡率趋势均显示出显著下降。结论：贝伦（亚马逊地区）和福塔莱萨（东北地区）60年代出生的女性胃癌发病率在上升。巴西东北地区死亡率上升，其他地区下降。需要亚马逊地区和东北地区更最新的发病率数据。
