Feldman S, Conforti N, Melamed E
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
Brain Res Bull. 1988 Oct;21(4):587-90. doi: 10.1016/0361-9230(88)90197-9.
The purpose of this study was to elucidate the role of norepinephrine (NE) in the mediation of adrenocortical responses following limbic stimuli. The effects of stimulation of the dorsal and ventral hippocampus and the midbrain reticular formation on the plasma corticosterone (CS) levels was studied in rats with vehicle or 6-hydroxydopamine (6-OHDA) injected bilaterally into the paraventricular nucleus of the hypothalamus (PVN). The injection of 6-OHDA caused a very significant reduction in the concentration of PVN NE and blocked the rise in plasma CS following the stimulation of the above three limbic structures. The basal CS level and the response to ether stress were not affected. The present study supports previous observations on the stimulatory role of NE on CS secretion and that the modulatory effects of extrahypothalamic limbic structures on the adrenocortical activity depend on the presence of NE in the PVN.
本研究的目的是阐明去甲肾上腺素（NE）在边缘系统刺激后介导肾上腺皮质反应中的作用。在双侧向大鼠下丘脑室旁核（PVN）注射载体或6-羟基多巴胺（6-OHDA）的情况下，研究了刺激背侧和腹侧海马以及中脑网状结构对血浆皮质酮（CS）水平的影响。注射6-OHDA导致PVN中NE浓度显著降低，并阻断了刺激上述三个边缘系统结构后血浆CS的升高。基础CS水平和对乙醚应激的反应未受影响。本研究支持先前关于NE对CS分泌具有刺激作用的观察结果，以及下丘脑外边缘系统结构对肾上腺皮质活动的调节作用取决于PVN中NE的存在。
