较高的膳食酸负荷与高血压风险升高相关：一项系统评价和荟萃分析。

Elevated hypertension risk associated with higher dietary acid load: A systematic review and meta-analysis.

作者信息

Chen Shao-Wei, Chen Zi-Hui, Liang Yu-Hui, Wang Ping, Peng Jie-Wen

机构信息

Department of Health Risk Assessment Research Center, Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, China.

Sun Yat-sen University Tung Wah Hospital, China.

出版信息

Clin Nutr ESPEN. 2019 Oct;33:171-177. doi: 10.1016/j.clnesp.2019.05.020. Epub 2019 Jun 21.

DOI:10.1016/j.clnesp.2019.05.020

PMID:31451256

Abstract

BACKGROUND & AIMS: The association between dietary acid load and hypertension risk is inconclusive. We conducted a systematic review and meta-analysis to summarize effect of dietary acid load on blood pressure.

METHODS

A comprehensively search was performed in electronic databases including EMBASE, PubMed, Web of Science and Chinese National Knowledge Infrastructure. Summary ORs and their corresponding 95% CIs were computed assuming a randomized model or fixed model.

RESULTS

Ten publications comprising 4 cohort and 6 cross-sectional studies were eligible for meta-analysis. There were 8 studies about potential renal acid load (PRAL) and 4 about net endogenous acid production (NEAP). Essential hypertension was statistically associated with higher PRAL (OR = 1.14, 95% CI = 1.02-1.17). Our findings also demonstrated a positive impact of higher PRAL on elevating both diastolic pressure (WMD = 0.96, 95% CI = 0.67-1.26) and systolic pressure (WMD = 1.57, 95% CI = 1.12-2.03). A 35% increased risk of hypertension associated with higher NEAP was identified (OR = 1.35, 95% CI = 1.03-1.78).

CONCLUSIONS

The current study suggests that dietary acid load might be potential risk factor of hypertension.

摘要

背景与目的

饮食酸负荷与高血压风险之间的关联尚无定论。我们进行了一项系统综述和荟萃分析，以总结饮食酸负荷对血压的影响。

方法

在包括EMBASE、PubMed、科学网和中国知网在内的电子数据库中进行了全面检索。采用随机模型或固定模型计算汇总OR值及其相应的95%CI。

结果

10篇文献（包括4项队列研究和6项横断面研究）符合荟萃分析的纳入标准。其中8项研究涉及潜在肾酸负荷（PRAL），4项研究涉及净内源性酸生成（NEAP）。原发性高血压与较高的PRAL存在统计学关联（OR = 1.14，95%CI = 1.02 - 1.17）。我们的研究结果还表明，较高的PRAL对舒张压（加权均数差[WMD] = 0.96，95%CI = 0.67 - 1.26）和收缩压（WMD = 1.57，95%CI = 1.12 - 2.03）升高均有积极影响。研究发现，较高的NEAP与高血压风险增加35%相关（OR = 1.35，95%CI = 1.03 - 1.78）。