Department of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang 43400, Malaysia.
Research Center of Excellence Nutrition and Non-Communicable Diseases, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang 43400, Malaysia.
Nutrients. 2021 Jun 23;13(7):2161. doi: 10.3390/nu13072161.
The objective of this study was to explore the effects of dietary acid load (DAL) and IGF1 and IL6 gene polymorphisms and their potential diet-gene interactions on metabolic traits. A total of 211 community-dwelling postmenopausal women were recruited. DAL was estimated using potential renal acid load (PRAL). Blood was drawn for biochemical parameters and DNA was extracted and Agena MassARRAY was used for genotyping analysis to identify the signalling of IGF1 (rs35767 and rs7136446) and IL6 (rs1800796) polymorphisms. Interactions between diet and genetic polymorphisms were assessed using regression analysis. The result showed that DAL was positively associated with fasting blood glucose (FBG) (β = 0.147, < 0.05) and there was significant interaction effect between DAL and IL6 with systolic blood pressure (SBP) (β = 0.19, = 0.041). In conclusion, these findings did not support the interaction effects between DAL and IGF1 and IL6 single nucleotide polymorphisms (rs35767, rs7136446, and rs1800796) on metabolic traits, except for SBP. Besides, higher DAL was associated with higher FBG, allowing us to postulate that high DAL is a potential risk factor for diabetes.
本研究旨在探讨饮食酸负荷（DAL）和 IGF1 和 IL6 基因多态性及其潜在的饮食-基因相互作用对代谢特征的影响。共招募了 211 名社区居住的绝经后妇女。使用潜在肾酸负荷（PRAL）估计 DAL。抽取血液进行生化参数检测，并提取 DNA，使用 Agena MassARRAY 进行基因分型分析，以鉴定 IGF1（rs35767 和 rs7136446）和 IL6（rs1800796）多态性的信号。通过回归分析评估饮食与遗传多态性之间的相互作用。结果表明，DAL 与空腹血糖（FBG）呈正相关（β=0.147，<0.05），且 DAL 与 IL6 与收缩压（SBP）之间存在显著的交互作用效应（β=0.19，=0.041）。总之，这些发现不支持 DAL 与 IGF1 和 IL6 单核苷酸多态性（rs35767、rs7136446 和 rs1800796）之间的交互作用对代谢特征的影响，除了 SBP。此外，较高的 DAL 与较高的 FBG 相关，这使我们可以假设高 DAL 是糖尿病的潜在危险因素。
