Certara, Inc., under contract with the Bill and Melinda Gates Foundation, Seattle, Washington, USA.
TB Alliance, New York, New York, USA.
Antimicrob Agents Chemother. 2019 Oct 22;63(11). doi: 10.1128/AAC.00463-19. Print 2019 Nov.
The bedaquiline regimen for the treatment of multidrug-resistant tuberculosis (MDR-TB) in adults is a loading dose of 400 mg QD for 2 weeks followed by 200 mg thrice weekly (TIW) for 22 weeks. Most TB antibiotics administered with bedaquiline are given QD. Using pharmacokinetic simulations, we explored alternative QD bedaquiline regimens and determined that 200 mg QD for 8 weeks followed by 100 mg QD provides comparable exposures to the approved regimen. This simpler regimen is under clinical evaluation.
贝达喹啉方案用于治疗成人耐多药结核病（MDR-TB），其剂量为 400mg，每日一次，共 2 周，随后 200mg，每周三次（TIW），共 22 周。大多数与贝达喹啉联合使用的抗结核药物均为每日一次给药。通过药代动力学模拟，我们探索了替代的每日一次贝达喹啉方案，并确定 200mg，每日一次，共 8 周，随后 100mg，每日一次，可提供与批准方案相当的暴露量。这种更简单的方案正在进行临床评估。
