使用3-羟基肉豆蔻酸（3HM）改进脓毒症患者血浆脂多糖（LPS）负荷的定量分析：一项队列研究 - Suppr

Improved quantification of plasma lipopolysaccharide (LPS) burden in sepsis using 3-hydroxy myristate (3HM): a cohort study.

作者信息

Dargent Auguste, Pais De Barros Jean-Paul, Ksiazek Elea, Fournel Isabelle, Dusuel Alois, Rerole Anne Laure, Choubley Hélène, Masson David, Lagrost Laurent, Quenot Jean-Pierre

机构信息

Médecine Intensive Réanimation, CHU Dijon-Bourgogne, 21000, Dijon, France.

LNC UMR1231, University Bourgogne Franche-Comté, 21000, Dijon, France.

出版信息

Intensive Care Med. 2019 Nov;45(11):1678-1680. doi: 10.1007/s00134-019-05749-0. Epub 2019 Aug 26.

DOI:10.1007/s00134-019-05749-0

PMID:31451860

Abstract

摘要

相似文献

Improved quantification of plasma lipopolysaccharide (LPS) burden in sepsis using 3-hydroxy myristate (3HM): a cohort study.使用3-羟基肉豆蔻酸（3HM）改进脓毒症患者血浆脂多糖（LPS）负荷的定量分析：一项队列研究

Intensive Care Med. 2019 Nov;45(11):1678-1680. doi: 10.1007/s00134-019-05749-0. Epub 2019 Aug 26.

[Prognostic value of lipopolysaccharide and lipopolysaccharide-binding protein serum levels in cancer patients with sepsis].[脂多糖和脂多糖结合蛋白血清水平在癌症合并脓毒症患者中的预后价值]

Zh Mikrobiol Epidemiol Immunobiol. 2011 Mar-Apr(2):82-4.

Lipopolysaccharide (LPS) from the cellular wall of Gram-negative bacteria, also known as endotoxin, is a key molecule in the pathogenesis of sepsis and septic shock. Preface.革兰氏阴性菌细胞壁中的脂多糖（LPS），也被称为内毒素，是脓毒症和脓毒性休克发病机制中的关键分子。前言。

Blood Purif. 2014;37 Suppl 1:1. doi: 10.1159/000357412. Epub 2014 Jan 20.

Identification of meningococcal LPS as a major monocyte activator in IL-10 depleted shock plasmas and CSF by blocking the CD14-TLR4 receptor complex.通过阻断CD14-TLR4受体复合物鉴定脑膜炎球菌脂多糖为白细胞介素-10缺失的休克血浆和脑脊液中的主要单核细胞激活剂。

J Endotoxin Res. 2003;9(3):155-63. doi: 10.1179/096805103125001559.

Impact of sepsis-induced changes in plasma on LPS interactions with monocytes and plasma lipoproteins: roles of soluble CD14, LBP, and acute phase lipoproteins.脓毒症诱导的血浆变化对脂多糖与单核细胞及血浆脂蛋白相互作用的影响：可溶性CD14、脂多糖结合蛋白及急性期脂蛋白的作用

J Endotoxin Res. 2003;9(2):113-8. doi: 10.1179/096805103125001504.

Characterization of changes in plasma and tissue oxylipin levels in LPS and CLP induced murine sepsis.脂多糖（LPS）和盲肠结扎穿孔术（CLP）诱导的小鼠脓毒症中血浆和组织氧化脂质水平变化的特征分析

Inflamm Res. 2016 Feb;65(2):133-42. doi: 10.1007/s00011-015-0897-7. Epub 2015 Dec 8.

Gastrointestinal and hepatic mechanisms limiting entry and dissemination of lipopolysaccharide into the systemic circulation.限制脂多糖进入和扩散至体循环的胃肠及肝脏机制。

Am J Physiol Gastrointest Liver Physiol. 2016 Jul 1;311(1):G1-G15. doi: 10.1152/ajpgi.00098.2016. Epub 2016 May 5.

A true theranostic approach to medicine: towards tandem sensor detection and removal of endotoxin in blood.医学上真正的治疗策略：实现血液中内毒素的串联传感器检测和清除。

Biosens Bioelectron. 2015 May 15;67:3-10. doi: 10.1016/j.bios.2014.07.008. Epub 2014 Jul 9.

Lipopolysaccharide binding by plasma proteins: an important protective effect?血浆蛋白与脂多糖的结合：一种重要的保护作用？

Crit Care Med. 2005 Jul;33(7):1664-6. doi: 10.1097/01.ccm.0000170179.14809.b0.

Effect of plasma and LPS on respiratory burst of neutrophils in septic patients.血浆和脂多糖对脓毒症患者中性粒细胞呼吸爆发的影响。

Intensive Care Med. 1998 Nov;24(11):1181-6. doi: 10.1007/s001340050742.

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Organ Failure, Endotoxin Activity, and Mortality in Septic Shock.脓毒性休克中的器官衰竭、内毒素活性与死亡率

Crit Care Explor. 2025 Aug 28;7(9):e1308. doi: 10.1097/CCE.0000000000001308. eCollection 2025 Sep 1.

Glucagon-like peptide 1 level and risk of death within 90 days after intensive care unit admission: A substudy of the IVOIRE cohort.胰高血糖素样肽1水平与重症监护病房入院后90天内的死亡风险：IVOIRE队列的一项子研究。

PLoS One. 2025 May 27;20(5):e0323709. doi: 10.1371/journal.pone.0323709. eCollection 2025.

Pneumococcal meningitis and endotoxemia: A cross-sectional clinical study.肺炎球菌性脑膜炎与内毒素血症：一项横断面临床研究。

PLoS One. 2025 May 21;20(5):e0324153. doi: 10.1371/journal.pone.0324153. eCollection 2025.

Risk factors and prognostic value of endotoxemia in patients with acute myocardial infarction.急性心肌梗死患者内毒素血症的危险因素及预后价值

Front Cardiovasc Med. 2024 Jun 25;11:1419001. doi: 10.3389/fcvm.2024.1419001. eCollection 2024.

Endotoxic Septic Shock: Diagnosis and Treatment.内毒素性感染性休克：诊断与治疗。

Int J Mol Sci. 2023 Nov 10;24(22):16185. doi: 10.3390/ijms242216185.

The role of endotoxin in septic shock.内毒素在感染性休克中的作用。

Crit Care. 2023 Oct 19;27(1):400. doi: 10.1186/s13054-023-04690-5.

Endotoxemia in Acute Heart Failure and Cardiogenic Shock: Evidence, Mechanisms and Therapeutic Options.急性心力衰竭和心源性休克中的内毒素血症：证据、机制与治疗选择

J Clin Med. 2023 Mar 29;12(7):2579. doi: 10.3390/jcm12072579.

Hemoperfusion in the intensive care unit.血液灌流在重症监护病房中的应用。

Intensive Care Med. 2022 Oct;48(10):1397-1408. doi: 10.1007/s00134-022-06810-1. Epub 2022 Aug 19.

Endotoxin Mass Concentration in Plasma Is Associated With Mortality in a Multicentric Cohort of Peritonitis-Induced Shock.血浆内毒素质量浓度与多中心腹膜炎诱发休克队列中的死亡率相关。

Front Med (Lausanne). 2021 Oct 29;8:749405. doi: 10.3389/fmed.2021.749405. eCollection 2021.

Increased Phospholipid Transfer Protein Activity Is Associated With Markers of Enhanced Lipopolysaccharide Clearance in Human During Cardiopulmonary Bypass.体外循环期间，人磷脂转运蛋白活性增加与脂多糖清除增强标志物相关。

Front Cardiovasc Med. 2021 Oct 12;8:756269. doi: 10.3389/fcvm.2021.756269. eCollection 2021.

本文引用的文献

Quantitative lipopolysaccharide analysis using HPLC/MS/MS and its combination with the limulus amebocyte lysate assay.使用高效液相色谱/串联质谱法进行脂多糖定量分析及其与鲎试剂检测法的联合应用。

J Lipid Res. 2015 Jul;56(7):1363-9. doi: 10.1194/jlr.D059725. Epub 2015 May 28.

Plasma PLTP (phospholipid-transfer protein): an emerging role in 'reverse lipopolysaccharide transport' and innate immunity.血浆 PLTP（磷脂转运蛋白）：在“反向脂多糖转运”和先天免疫中的新作用。

Biochem Soc Trans. 2011 Aug;39(4):984-8. doi: 10.1042/BST0390984.

Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease.饮食、共生菌和肠道作为动脉粥样硬化、2 型糖尿病和非酒精性脂肪性肝病中病原体相关分子模式的来源。

Atherosclerosis. 2011 May;216(1):1-6. doi: 10.1016/j.atherosclerosis.2011.02.043. Epub 2011 Feb 26.

Lipoproteins in inflammation and sepsis. II. Clinical aspects.炎症与脓毒症中的脂蛋白。II. 临床方面

Intensive Care Med. 2007 Jan;33(1):25-35. doi: 10.1007/s00134-006-0433-x. Epub 2006 Nov 9.

The detection and interpretation of endotoxaemia.内毒素血症的检测与解读。

Intensive Care Med. 2000;26 Suppl 1:S51-6. doi: 10.1007/s001340051119.

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Improved quantification of plasma lipopolysaccharide (LPS) burden in sepsis using 3-hydroxy myristate (3HM): a cohort study.

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