Department of Stomatology, People's Hospital Longhua Shenzhen, Shenzhen, Guangdong, China.
Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
J Cell Biochem. 2020 Jan;121(1):867-875. doi: 10.1002/jcb.29331. Epub 2019 Aug 26.
Long noncoding RNAs (lncRNAs) are linked to tumor development and progression. The aim of this study was to determine the prognostic significance and biological role of LINC01116 in head and neck squamous cell carcinoma (HNSCC). We identified 21 aberrantly expressed lncRNAs specific to HNSCC that were common in two microarray datasets. LINC01116 was highly overexpressed in HNSCC tissues and was correlated to shorter overall survival and relapse-free survival duration, as analyzed by the online Gene Expression Profiling Interactive Analysis platform. LINC01116 was also overexpressed in oral squamous cell carcinoma and nasopharyngeal carcinoma tissues, and LINC01116 silencing significantly inhibited the migration and invasion capacities of both cell lines by blocking the epithelial-mesenchymal transition process. In addition, 125 coexpressing genes were identified by circlncRNAnet, and were mainly located on human autosomes and enriched in transforming growth factor-β signaling pathway. These findings indicate that LINC01116 might be a potential therapeutic target for HNSCC.
长链非编码 RNA（lncRNAs）与肿瘤的发生和发展有关。本研究旨在确定 LINC01116 在头颈部鳞状细胞癌（HNSCC）中的预后意义和生物学作用。我们鉴定了 21 种在两个微阵列数据集中共有的特定于 HNSCC 的异常表达的 lncRNAs。通过在线基因表达谱交互式分析平台分析，LINC01116 在 HNSCC 组织中高度过表达，与总生存期和无复发生存期缩短相关。LINC01116 在口腔鳞状细胞癌和鼻咽癌组织中也过表达，LINC01116 沉默通过阻断上皮-间充质转化过程显著抑制了这两种细胞系的迁移和侵袭能力。此外，通过 circlncRNAnet 鉴定出 125 个共表达基因，这些基因主要位于人类常染色体上，并富集在转化生长因子-β信号通路中。这些发现表明 LINC01116 可能是 HNSCC 的潜在治疗靶点。
