Gordon C A, Hodges N A, Marriott C
Department of Pharmacy, Brighton Polytechnic, Moulsecoomb, Brighton, UK.
J Antimicrob Chemother. 1988 Nov;22(5):667-74. doi: 10.1093/jac/22.5.667.
The interaction of five anti-pseudomonas antibiotics with both commercial and pseudomonas alginates was studied by investigation of their binding and diffusion characteristics. The two sources of alginate were qualitatively but not quantitatively similar in these respects. Unlike the beta-lactams, gentamicin and tobramycin bound avidly to both sources of alginate and, when the alginate gel to antibiotic ratio was high, the aminoglycosides exhibited diffusion coefficients which were approximately 20% of the beta-lactam values. At much lower ratios of alginate to antibiotic the aminoglycosides caused precipitation in the alginate with apparent disruption of the gel structure, and ultimately penetrated the gel at a faster rate than the beta-lactams. The strong aminoglycoside binding to alginate was reduced, but not eliminated by the presence of physiological concentrations of salts.
通过研究五种抗假单胞菌抗生素与市售藻酸盐和假单胞菌藻酸盐的结合及扩散特性，对它们之间的相互作用进行了研究。在这些方面，这两种藻酸盐来源在性质上相似，但在数量上并不相同。与β-内酰胺类抗生素不同，庆大霉素和妥布霉素能与两种藻酸盐来源紧密结合，当藻酸盐凝胶与抗生素的比例较高时，氨基糖苷类抗生素的扩散系数约为β-内酰胺类抗生素的20%。在藻酸盐与抗生素比例低得多的情况下，氨基糖苷类抗生素会在藻酸盐中引起沉淀，导致凝胶结构明显破坏，最终比β-内酰胺类抗生素更快地穿透凝胶。生理浓度的盐会降低氨基糖苷类抗生素与藻酸盐的强烈结合，但不会消除这种结合。
