Basso D, Fabris C, Panucci A, Del Favero G, Angonese C, Plebani M, Petrin P, Burlina A, Naccarato R
Istituto di Medicina Interna (Cattedra di Malattie Apparato Digerente), Policlinico Universitario, Padova, Italy.
Int J Pancreatol. 1988;3 Suppl 1:S95-100.
The clinical usefulness of tissue polypeptide antigen, galactosyltransferase II and pancreatic oncofetal antigen was evaluated in detecting pancreatic cancer and in differentiating this malignancy from chronic pancreatitis and other diseases (mainly of the liver and biliary tract) which may enter in differential diagnosis. TPA seems to be the most sensitive among these indices in detecting pancreatic cancer and appears to discriminate this malignancy quite satisfactorily from chronic pancreatitis. It is also frequently pathological in a number of other diseases and is influenced by the presence of liver dysfunction. GT II and POA do not grossly differ from TPA in specificity, but they appear to be less sensitive. Both are frequently pathological in hepato-biliary diseases. All these markers seem, therefore, to be of limited value in the diagnosis of pancreatic cancer.
对组织多肽抗原、半乳糖基转移酶II和胰腺癌胚抗原在检测胰腺癌以及将这种恶性肿瘤与慢性胰腺炎和其他可能参与鉴别诊断的疾病（主要是肝脏和胆道疾病）进行鉴别诊断方面的临床实用性进行了评估。在检测胰腺癌方面，TPA似乎是这些指标中最敏感的，并且似乎能相当令人满意地将这种恶性肿瘤与慢性胰腺炎区分开来。在许多其他疾病中它也经常呈病理性，并且受肝功能障碍的影响。GT II和POA在特异性方面与TPA没有显著差异，但它们似乎不太敏感。在肝胆疾病中两者经常呈病理性。因此，所有这些标志物在胰腺癌的诊断中似乎价值有限。
