Bruine de Bruin Leonie, Wachters Jan E, Schrijvers Michiel L, Slagter-Menkema Lorian, Mastik Mirjam F, Langendijk Johannes A, van der Wal Jacqueline E, Schuuring Ed, van der Laan Bernard F A M
Department of Otorhinolaryngology/Head and Neck Surgery University Medical Center Groningen, University of Groningen Groningen The Netherlands.
Graduate School of Medical Sciences (Groningen University Institute for Drug Exploration) University of Groningen Groningen The Netherlands.
Laryngoscope Investig Otolaryngol. 2019 Jun 12;4(4):399-404. doi: 10.1002/lio2.272. eCollection 2019 Aug.
The aim of this study was to establish the prognostic value of the epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression on local control in patients with early stage supraglottic laryngeal squamous cell carcinoma (LSCC) treated with radiotherapy only.
Retrospective cohort study.
Immunohistochemical staining for EGFR and PTEN was performed on pretreatment biopsies of a selected well-defined homogeneous group of 52 patients with T1-T2 supraglottic LSCC treated with radiotherapy between 1990 and 2008. Kaplan-Meier analysis and univariate and multivariate Cox Regression analyses were performed to correlate clinical data and expression levels of EGFR and PTEN with local control.
Kaplan-Meier survival analysis and Cox Regression analysis showed a significant association between PTEN expression and local control (hazard ratio [HR] = 3.26, 95% confidence interval [CI] = 1.14-9.33, = .027) and between lymph node status and local control (HR = 3.60, 95% CI = 1.26-10.31, = .017). Both were independent prognostic factors in a multivariate analysis (HR = 3.28, 95% CI = 1.14-9.39, = .027 and HR = 3.62, 95% CI = 1.26-10.37, = .017, respectively). There was no significant association between EGFR expression and local control (HR = 1.32, 95% CI = 1.17-10.14, = .79).
This study showed an association between both high PTEN expression and the presence of lymph node metastasis and deteriorated local control in early stage supraglottic LSCC treated with radiotherapy.
NA.
本研究旨在确定表皮生长因子受体（EGFR）和第10号染色体缺失的磷酸酶和张力蛋白同源物（PTEN）表达对仅接受放疗的早期声门上型喉鳞状细胞癌（LSCC）患者局部控制的预后价值。
回顾性队列研究。
对1990年至2008年间接受放疗的52例T1-T2声门上型LSCC患者的预处理活检标本进行EGFR和PTEN免疫组化染色。采用Kaplan-Meier分析以及单因素和多因素Cox回归分析，将临床数据以及EGFR和PTEN的表达水平与局部控制情况进行关联分析。
Kaplan-Meier生存分析和Cox回归分析显示，PTEN表达与局部控制之间存在显著关联（风险比[HR]=3.26，95%置信区间[CI]=1.14-9.33，P=.027），淋巴结状态与局部控制之间也存在显著关联（HR=3.60，95%CI=1.26-10.31，P=.017）。在多因素分析中，二者均为独立的预后因素（HR分别为3.28，95%CI=1.14-9.39，P=.027和HR=3.62，95%CI=1.26-10.37，P=.017）。EGFR表达与局部控制之间无显著关联（HR=1.32，95%CI=1.17-10.14，P=.79）。
本研究表明，在接受放疗的早期声门上型LSCC中，PTEN高表达以及存在淋巴结转移均与局部控制恶化相关。
无。
