Altınbilek Turgay, Terzi Rabia, Başaran Aynur, Tolu Sena, Küçüksaraç Seher
Department of Physiotherapy and Rehabilitation, İstanbul Kültür University, Faculty of Health Sciences, İstanbul, Turkey.
Department of Physical Therapy and Rehabilitation, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.
Turk J Phys Med Rehabil. 2019 Jan 23;65(1):1-8. eCollection 2019 Mar.
This study aims to compare the effects of neural therapy and exercise on pain, quality of life, depression, anxiety, and functioning status in patients diagnosed with fibromyalgia syndrome (FMS).
This multi-center study included a total of 72 patients (60 females, 12 males; mean age: 39.2±9.5 years; range, 22 to 53 years) who were diagnosed with FMS according to the 1990 American College of Rheumatology (ACR) criteria between January 2015 and June 2015. The patients were randomly divided into two groups: the first group (n=30) received an exercise program (strengthening, stretching, relaxation, and aerobic exercises, three days a week), and the second group (n=42) received a total of six sessions of neural therapy as one session a week in addition to the same exercise program. Pain severity was assessed with the Visual Analog Scale (VAS), emotional state with the Beck Depression Scale (BDS) and Beck Anxiety Inventory (BAI), quality of life with Short Form-36 (SF-36), and functioning status with the Fibromyalgia Impact Questionnaire (FIQ). The patients were evaluated at the end of treatment (week 6) and one month after the end of treatment.
The mean disease duration was 34.3±9.3 months, the mean VAS score was 7.3±2.2, and the mean FIQ score was 58.4±13.2. There were significant improvements in the VAS, FIQ, SF-36, BDS, and BAI scores after the treatment in both groups (p<0.05). Post-treatment BDS and VAS scores were significantly lower in the neural therapy group (p=0.038; p=0.049; p<0.05). There was no significant difference in any parameter one month after the treatment between the groups (p>0.05).
When neural therapy is combined with exercise in FMS patients, it may be advantageous in terms of pain and depression, compared to exercise alone.
本研究旨在比较神经疗法和运动对诊断为纤维肌痛综合征（FMS）患者的疼痛、生活质量、抑郁、焦虑和功能状态的影响。
这项多中心研究共纳入72例患者（60例女性，12例男性；平均年龄：39.2±9.5岁；范围22至53岁），这些患者在2015年1月至2015年6月期间根据1990年美国风湿病学会（ACR）标准被诊断为FMS。患者被随机分为两组：第一组（n = 30）接受运动计划（强化、伸展、放松和有氧运动，每周三天），第二组（n = 42）除了相同的运动计划外，每周接受一次共六次的神经疗法。用视觉模拟量表（VAS）评估疼痛严重程度，用贝克抑郁量表（BDS）和贝克焦虑量表（BAI）评估情绪状态，用简短健康调查量表（SF - 36）评估生活质量，用纤维肌痛影响问卷（FIQ）评估功能状态。在治疗结束时（第6周）和治疗结束后1个月对患者进行评估。
平均病程为34.3±9.3个月，平均VAS评分为7.3±2.2，平均FIQ评分为58.4±13.2。两组治疗后VAS、FIQ、SF - 36、BDS和BAI评分均有显著改善（p < 0.05）。神经疗法组治疗后的BDS和VAS评分显著更低（p = 0.038；p = 0.049；p < 0.05）。治疗后1个月两组在任何参数上均无显著差异（p > 0.05）。
在FMS患者中，神经疗法与运动相结合时，与单纯运动相比，在疼痛和抑郁方面可能具有优势。
