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利用石莼开发广谱载有菌孢素的防晒配方。

Development of broad spectrum mycosporine loaded sunscreen formulation from Ulva fasciata delile.

作者信息

Bhatia Saurabh, Sardana Satish, Sharma Ajay, Vargas De La Cruz Celia Bertha, Chaugule Bhupal, Khodaie Laleh

机构信息

Amity institute of pharmacy, Amity University Haryana, Gurgaon, Haryana-122413, India.

Amity Institute of Pharmacy, Amity University Madhya Pradesh, Maharajpura, Gwalior (MP)-474005, India.

出版信息

Biomedicine (Taipei). 2019 Sep;9(3):17. doi: 10.1051/bmdcn/2019090317. Epub 2019 Aug 27.

Abstract

UNLABELLED

Ba.ckground: Sunscreen formulations primarily offer protection against UV induced damages however nowadays it also maintains skin natural physiological conditions. Current global market is flooded with numerous sunscreen products which offer protection to skin against several UV induced damages. However most of these sunscreen formulations offers narrow spectrum protection against UV and also suffer from stability as well as toxicity related issues.

METHODS

Present work aims to isolate mycosporine amino acid (Mgy) from green alga namely Ulva fasciata (U. fasciata) and study its sunscreen potential against widely used domestic marketed formulation. Stability evaluations were also performed for almost 90 days.

RESULTS

Results demonstrated that the isolated compound, mycosporine glycine (Mgy) preserved physicochemical properties of the product and offered good stability for all formulations throughout the experimental period. Furthermore, Mgy loaded carbopol gel showed better sunscreen protection against marketed formulation in a concentration dependent manner. (7.709).

CONCLUSION

(6.806) Novel Myg loaded gel was proved to demonstrate several quality characteristics that may unlock new prospects for the production of more efficient, safe, and economic skin-care products.

摘要

未标注

背景:防晒配方主要提供针对紫外线诱导损伤的防护,然而如今它还能维持皮肤的自然生理状态。当前全球市场充斥着众多为皮肤提供针对多种紫外线诱导损伤防护的防晒产品。然而,这些防晒配方大多提供窄谱紫外线防护,并且还存在稳定性以及毒性相关问题。

方法

当前工作旨在从绿藻石莼中分离出肌氨酸氨基酸(Mgy),并研究其相对于广泛使用的国内市售配方的防晒潜力。还进行了近90天的稳定性评估。

结果

结果表明,分离出的化合物肌氨酸甘氨酸(Mgy)保持了产品的物理化学性质,并且在整个实验期间为所有配方提供了良好的稳定性。此外,负载Mgy的卡波姆凝胶以浓度依赖的方式显示出比市售配方更好的防晒保护。(7.709)

结论

(6.806)新型负载Myg的凝胶被证明具有多种质量特性,这可能为生产更高效、安全和经济的护肤品开辟新前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1344/6711319/0d42c8eae186/bmdcn-9-17-fig1.jpg

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