Department of Clinical Pharmacy, School of Pharmacy, University of Gondar-College of Medicine and Health Sciences, Gondar, Ethiopia.
PLoS One. 2019 Aug 27;14(8):e0221790. doi: 10.1371/journal.pone.0221790. eCollection 2019.
Ethiopia recorded the highest numbers of people with diabetes in Africa. It is not uncommon for diabetic patients to have poor glycemic control leading to a number of complications. The aim of this systematic review and meta-analysis is to evaluate the level of glycemic control among diabetic patients in Ethiopia by combining the studies from the existing literature.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was employed to plan and conduct this review. A comprehensive electronic-based literature search was conducted in the databases of MEDLINE, HINARI, GOOGLE SCHOLAR, and SCIENCEDIRECT. Open meta-analyst software was used to perform meta-analyses. Proportions of good glycemic control among diabetic patients was calculated. Odds ratio was also calculated to check the presence of statistically significant difference in glycemic control among patients with type 1 and type 2 diabetes.
A total of 22 studies were included in the final analysis. Meta-analysis of 16 studies showed that only one-third of patients [34.4% (95% CI: 27.9%-40.9%), p<0.001] achieving good glycemic control based on fasting plasma glucose measurements. Similar to the studies that used fasting plasma glucose, the rate of good glycemic control was found to be 33.2% [(95% CI: 21.8%-44.6%), p<0.001] based on glycosylated hemoglobin measurements. There was no statistically significant difference in the rates of glycemic control between patients with type 1 and type 2 diabetes (p = 0.167).
High proportion of diabetic patients were unable to achieve good glycemic control. There was no difference in glycemic control among type 1 and type 2 diabetic patients.
埃塞俄比亚是非洲糖尿病患者人数最多的国家。糖尿病患者血糖控制不佳导致多种并发症并不罕见。本系统评价和荟萃分析的目的是通过结合现有文献中的研究来评估埃塞俄比亚糖尿病患者的血糖控制水平。
本研究采用系统评价和荟萃分析的首选报告项目（PRISMA）指南进行规划和实施。我们在 MEDLINE、HINARI、GOOGLE SCHOLAR 和 SCIENCEDIRECT 数据库中进行了全面的电子文献检索。使用 Open Meta-Analyst 软件进行荟萃分析。计算糖尿病患者良好血糖控制的比例。还计算了比值比，以检查 1 型和 2 型糖尿病患者血糖控制是否存在统计学显著差异。
共有 22 项研究纳入最终分析。16 项研究的荟萃分析表明，只有三分之一的患者[34.4%（95%CI：27.9%-40.9%），p<0.001]根据空腹血糖测量值达到良好的血糖控制。与使用空腹血糖的研究相似，根据糖化血红蛋白测量值，良好血糖控制的比例为 33.2%[（95%CI：21.8%-44.6%），p<0.001]。1 型和 2 型糖尿病患者的血糖控制率无统计学显著差异（p = 0.167）。
相当一部分糖尿病患者无法实现良好的血糖控制。1 型和 2 型糖尿病患者的血糖控制无差异。
