Tarekegn Endalkachew Tedila, Gobezie Mengistie Yirsaw, Haile Melese Belete, Zerga Aregash Abebayehu
Department of Epidemiology and Biostatistics, School of Public Health, Colleges of Medicine and Health Science, Wollo University, Dessie, Ethiopia.
Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Sci Rep. 2025 Mar 18;15(1):9286. doi: 10.1038/s41598-025-93739-2.
Effective glycemic control is essential for managing diabetes-related complications. While studies in Ethiopia have shown poor glycemic control based on fasting blood glucose levels, further research using the glycated hemoglobin (HbA1c) test is necessary. This study aimed to evaluate glycemic control and identify associated factors among patients with type 2 diabetes. A hospital-based cross-sectional study was conducted from February 1 to March 30, 2023, involving 465 type 2 diabetes patients. Socio-demographic and clinical data were collected using a semi-structured questionnaire through consecutive sampling. Laboratory tests, including glycated hemoglobin, fasting blood sugar, renal function, and lipid profiles, were performed. Data analysis was carried out using Epi-data version 4.6.0.4 and SPSS version 26, employing descriptive statistics and binary logistic regression. Multivariable analysis was performed on variables with P < 0.25. The results were presented using numbers, frequencies, and tables. Approximately 73.5% (95% CI = 69.5, 77.4) of the patients demonstrated poor glycemic control. Factors associated with poor glycemic control were lack of formal education (AOR = 4.94, 95% CI = 2.99, 8.15), obesity (AOR = 5.32, 95% CI = 2.02, 14.04), overweight (AOR = 3.77, 95% CI = 1.65, 8.63), high total cholesterol (AOR = 7.79, 95% CI = 4.44, 13.66), and a diabetes duration of more than 10 years (AOR = 3.32, 95% CI = 1.87, 5.89). The research highlights a significant proportion of diabetic patients with inadequate glycemic control, which is associated with factors such as education level, BMI, total cholesterol, and the duration of diabetes. Addressing these factors through personalized management strategies is essential for improving glycemic control and reducing complications.
有效的血糖控制对于管理糖尿病相关并发症至关重要。虽然埃塞俄比亚的研究表明基于空腹血糖水平的血糖控制不佳，但有必要使用糖化血红蛋白（HbA1c）检测进行进一步研究。本研究旨在评估2型糖尿病患者的血糖控制情况并确定相关因素。2023年2月1日至3月30日进行了一项基于医院的横断面研究，纳入了465例2型糖尿病患者。通过连续抽样，使用半结构化问卷收集社会人口统计学和临床数据。进行了实验室检测，包括糖化血红蛋白、空腹血糖、肾功能和血脂谱。使用Epi-data 4.6.0.4版和SPSS 26版进行数据分析，采用描述性统计和二元逻辑回归。对P<0.25的变量进行多变量分析。结果以数字、频率和表格形式呈现。约73.5%（95%CI=69.5，77.4）的患者血糖控制不佳。与血糖控制不佳相关的因素包括未接受正规教育（比值比[AOR]=4.94，95%CI=2.99，8.15）、肥胖（AOR=5.32，95%CI=2.02，14.04）、超重（AOR=3.77，95%CI=1.65，8.63）、总胆固醇高（AOR=7.79，95%CI=4.44，13.66）以及糖尿病病程超过10年（AOR=3.32，95%CI=1.87，5.89）。该研究突出了相当一部分血糖控制不佳的糖尿病患者，这与教育水平、体重指数、总胆固醇和糖尿病病程等因素有关。通过个性化管理策略解决这些因素对于改善血糖控制和减少并发症至关重要。
