Department of Chemistry, Duke University, Durham, NC 27708, United States.
Department of Chemistry, Duke University, Durham, NC 27708, United States; School of Medicine, Duke University, Durham, NC 27708, United States.
J Magn Reson. 2019 Oct;307:106577. doi: 10.1016/j.jmr.2019.106577. Epub 2019 Aug 17.
Signal Amplification By Reversible Exchange, or SABRE, uses the singlet-order of parahydrogen to generate hyperpolarized signals on target nuclei, bypassing the limitations of traditional magnetic resonance. Experiments performed directly in the magnet provide a route to generate large magnetizations continuously without having to field-cycle the sample. For heteronuclear SABRE, these high-field methods have been restricted to the few SABRE complexes that exhibit efficient exchange with symmetric ligand environments as co-ligands induce chemical shift differences between the parahydrogen-derived hydrides, destroying the hyperpolarized spin order. Through careful consideration of the underlying spin physics, we introduce H decoupled LIGHT-SABRE pulse sequence variants which bypasses this limitation, drastically expanding the scope of heteronuclear SABRE at high field.
信号放大可逆交换，或 SABRE，利用单重态的 para 氢生成目标核的超极化信号，绕过了传统磁共振的限制。在磁体中直接进行的实验提供了一种连续产生大磁化的途径，而无需对样品进行磁场循环。对于异核 SABRE，这些高场方法一直受到少数 SABRE 配合物的限制，这些配合物与对称配体环境有效交换作为共配体，在 parahydrogen 衍生的氢化物之间诱导化学位移差异，破坏超极化自旋顺序。通过对潜在自旋物理的仔细考虑，我们引入了 H 去耦 LIGHT-SABRE 脉冲序列变体，该变体绕过了这一限制，极大地扩展了高场异核 SABRE 的范围。
