Kołodziej Magdalena, Waszczykowska Arleta, Korzeniewska-Dyl Irmina, Pyziak-Skupien Aleksandra, Walczak Konrad, Moczulski Dariusz, Jurowski Piotr, Młynarski Wojciech, Szadkowska Agnieszka, Zmysłowska Agnieszka
Department of Practical Obstetrics, Medical University of Lodz, 90-419 Lodz, Poland.
Department of Ophthalmology and Vision Rehabilitation, Medical University of Lodz, 90-419 Lodz, Poland.
Diagnostics (Basel). 2019 Aug 26;9(3):105. doi: 10.3390/diagnostics9030105.
The aim of the study was to analyze the thickness of individual retinal layers in patients with type 1 diabetes (T1D) in comparison to the control group and in relation to markers of diabetes metabolic control. The study group consisted of 111 patients with an average of 6-years of T1D duration. The control group included 36 gender- and age-matched individuals. In all patients optical coherence tomography (OCT) study was performed using HD-OCT Cirrus 5000 with evaluation of optic nerve head (ONH) parameters, thickness of retinal nerve fiber layer (RNFL) with its quadrants, macular full-thickness parameters, ganglion cells with inner plexus layer (GCIPL) and choroidal thickness (CT). Lower disc area value was observed in the study group as compared to controls ( = 0.0215). Negative correlations were found both between age at examination and rim area (R = -0.28, = 0.0007) and between superior RNFL thickness and duration of diabetes (R = -0.20, = 0.0336). Positive correlation between center thickness and SD for average glycemia (R = 0.30, = 0.0071) was noted. Temporal CT correlated positively with age at examination (R = 0.21, = 0.0127). The selected parameters the HD-OCT study may in the future serve as potential markers of preclinical phase of DR in patients with T1D.
本研究的目的是分析1型糖尿病（T1D）患者与对照组相比的各视网膜层厚度，并探讨其与糖尿病代谢控制指标的关系。研究组由111例平均患T1D 6年的患者组成。对照组包括36例性别和年龄匹配的个体。所有患者均使用HD-OCT Cirrus 5000进行光学相干断层扫描（OCT）研究，评估视神经乳头（ONH）参数、视网膜神经纤维层（RNFL）及其象限的厚度、黄斑全层参数、神经节细胞与内丛状层（GCIPL）以及脉络膜厚度（CT）。与对照组相比，研究组的视盘面积值较低（P = 0.0215）。在检查年龄与视盘边缘面积之间（R = -0.28，P = 0.0007）以及上方RNFL厚度与糖尿病病程之间（R = -0.20，P = 0.0336）均发现负相关。中心厚度与平均血糖标准差之间呈正相关（R = 0.30，P = 0.0071）。颞侧CT与检查年龄呈正相关（R = 0.21，P = 0.0127）。HD-OCT研究中选定的参数未来可能作为T1D患者糖尿病视网膜病变临床前期的潜在标志物。
