Internal Medicine and Critical Subacute Care Unit, Medicine Geriatric-Rehabilitation Department and Department of Medicine and Surgery, University-Hospital of Parma, 43121 Parma, Italy.
Internal Medicine Unit, Pavullo Hospital, Azienda USL, 41026 Modena, Italy.
Int J Environ Res Public Health. 2019 Aug 26;16(17):3104. doi: 10.3390/ijerph16173104.
New evidence suggests that non-alcoholic fatty liver disease (NAFLD) has a strong multifaceted relationship with diabetes and metabolic syndrome, and is associated with increased risk of cardiovascular events, regardless of traditional risk factors, such as hypertension, diabetes, dyslipidemia, and obesity. Given the pandemic-level rise of NAFLD-in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome-and its association with poor cardiovascular outcomes, the question of how to manage NAFLD properly, in order to reduce the burden of associated incident cardiovascular events, is both timely and highly relevant. This review aims to summarize the current knowledge of the association between NAFLD and cardiovascular disease, and also to discuss possible clinical strategies for cardiovascular risk assessment, as well as the spectrum of available therapeutic strategies for the prevention and treatment of NAFLD and its downstream events.
新证据表明，非酒精性脂肪性肝病（NAFLD）与糖尿病和代谢综合征之间存在着复杂的强关联，并且与心血管事件风险的增加相关，无论是否存在高血压、糖尿病、血脂异常和肥胖等传统危险因素。鉴于 NAFLD 的流行程度呈上升趋势——与肥胖和代谢综合征的其他成分的流行程度同时上升——以及它与不良心血管结局的关联，因此，如何正确管理 NAFLD 以降低相关心血管事件的负担，这既是及时的，也是高度相关的。本综述旨在总结 NAFLD 与心血管疾病之间的关联的现有知识，并讨论用于心血管风险评估的可能临床策略，以及用于预防和治疗 NAFLD 及其下游事件的现有治疗策略。
