糖尿病和非糖尿病非酒精性脂肪性肝病患者心血管危险因素的调查。
Investigation of cardiovascular risk factors in diabetic and nondiabetic patients with nonalcoholic fatty liver disease.
作者信息
Barati Mona, Teimouri Azam, Feizi Awat, Iraj Bijan, Karimifar Mozhgan
机构信息
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Res Med Sci. 2024 Aug 2;29:51. doi: 10.4103/jrms.jrms_830_23. eCollection 2024.
BACKGROUND
The current study aims to assess cardiovascular risk factors (CVRFs) among diabetic versus nondiabetic nonalcoholic fatty liver disease (NAFLD) patients. NAFLD is the most common hepatic disorder worldwide which is directly associated with diverse CVRFs such as type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS).
MATERIALS AND METHODS
The current cross-sectional population-based study has been conducted on 1031 NAFLD patients. After excluding 340 prediabetes patients, the NAFLD patients were divided into T2DM and normal blood glucose (NBG). Then, CVRFs were compared between the two groups.
RESULTS
Out of 691 NAFLD cases included in the study, 337 (48.8%) patients had T2DM. In the T2DM and NBG groups, the body mass index (BMI) was 31.2 ± 4.6 and 29.9 ± 4.3 kg/m2, respectively (P = 0.001). The waist circumference was 102.2 ± 10.2 and 97.6 ± 10.6 cm, respectively (P < 0.001). The systolic blood pressure was 123.3 ± 15.6 and 119.6 ± 13.6 mmHg, respectively (P = 0.043). The triglyceride levels were 191.9 ± 104.7 and 176.5 ± 89.6 mg/dL, respectively (P = 0.042). Generally, these factors were significantly higher among the diabetic patients. Besides, cardiovascular disease (CVD), hypertension, and MS were statistically more prevalent in NAFLD patients with T2DM ( < 0.001) than nondiabetic NAFLD patients. In multiple logistic regression models, the odds ratio of CVD, hypertension, and MS was 2.18, 2.12, and 6.63 for patients with T2DM compared with NBG, respectively. Adjustment was made for age, sex, BMI, smoking, and physical activity.
CONCLUSION
CVRFs were higher in NAFLD patients with T2DM than NAFLD patients with NBG.
背景
本研究旨在评估糖尿病与非糖尿病非酒精性脂肪性肝病（NAFLD）患者的心血管危险因素（CVRF）。NAFLD是全球最常见的肝脏疾病，与多种CVRF直接相关，如2型糖尿病（T2DM）和代谢综合征（MS）。
材料与方法
本横断面基于人群的研究对1031例NAFLD患者进行。排除340例糖尿病前期患者后，将NAFLD患者分为T2DM组和血糖正常（NBG）组。然后，比较两组的CVRF。
结果
纳入研究的691例NAFLD病例中，337例（48.8%）患者患有T2DM。在T2DM组和NBG组中，体重指数（BMI）分别为31.2±4.6和29.9±4.3kg/m²（P=0.001）。腰围分别为102.2±10.2和97.6±10.6cm（P<0.001）。收缩压分别为123.3±15.6和119.6±13.6mmHg（P=0.043）。甘油三酯水平分别为191.9±104.7和176.5±89.6mg/dL（P=0.042）。总体而言，这些因素在糖尿病患者中显著更高。此外，心血管疾病（CVD）、高血压和MS在T2DM的NAFLD患者中（<0.001）比非糖尿病NAFLD患者在统计学上更普遍。在多因素逻辑回归模型中，与NBG相比，T2DM患者发生CVD、高血压和MS的比值比分别为2.18、2.12和6.63。对年龄、性别、BMI、吸烟和体力活动进行了校正。
结论
T2DM的NAFLD患者的CVRF高于NBG的NAFLD患者。
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