Department of Intensive Care Medicine, Derriford Hospital, 6634University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom.
Faculty of Medicine and Dentistry, 6634University of Plymouth, Plymouth, United Kingdom.
J Intensive Care Med. 2020 Dec;35(12):1564-1575. doi: 10.1177/0885066619871452. Epub 2019 Aug 27.
Multiple organ dysfunction syndrome (MODS) is one of the most common syndromes of critical illness and the leading cause of mortality among critically ill patients. Multiple organ dysfunction syndrome is the clinical consequence of a dysregulated inflammatory response, triggered by clinically diverse factors with the main pillar of management being invasive organ support. During the last years, the advances in the clarification of the molecular pathways that trigger, mitigate, and determine the outcome of MODS have led to the increasing recognition of MODS as a distinct disease entity with distinct etiology, pathophysiology, and potential future therapeutic interventions. Given the lack of effective treatment for MODS, its early recognition, the early intensive care unit admission, and the initiation of invasive organ support remain the most effective strategies of preventing its progression and improving outcomes.
多器官功能障碍综合征（MODS）是危重病中最常见的综合征之一，也是危重病患者死亡的主要原因。多器官功能障碍综合征是炎症反应失调的临床后果，由临床多种因素引发，其主要治疗方法是侵袭性器官支持。在过去几年中，对触发、减轻和决定 MODS 结果的分子途径的阐明取得了进展，这导致人们越来越认识到 MODS 是一种具有独特病因、病理生理学和潜在未来治疗干预的独特疾病实体。鉴于 MODS 缺乏有效治疗方法，早期识别、早期入住重症监护病房和开始侵袭性器官支持仍然是预防其进展和改善预后的最有效策略。
